| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313180 |
| ISSN: | 0100-4042 |
| Authors: | Lozano, Hernán R1 Martínez, Fleming |
| Institutions: | 1Universidad Nacional de Colombia, Departamento de Farmacia, Bogotá. Colombia |
| Year: | 2006 |
| Season: | Jul |
| Volumen: | 29 |
| Number: | 4 |
| Pages: | 704-709 |
| Country: | Brasil |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The thermodynamics of molal partitioning of ketoprofen (KTP) was studied in cyclohexane/buffer (CH/W), octanol/buffer (ROH/W), and dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and egg lecithin (EGG/W) liposome systems. In all cases the partition coefficients (Kmo/w)were greater than unity; therefore the standard free energies of transfer were negative indicating affinity of KTP for organic media. The Kmo/w values were approximately seventy-fold higher in the ROH/W system compared with the CH/W system. On the other hand, the Kmo/w values were approximately ten or fifty-fold higher in the liposomes compared with the ROH/W system. In all cases, the standard enthalpies and entropies of transfer of KTP were positive indicating some degree of participation of the hydrophobic hydration on partitioning processes |
| Disciplines: | Química |
| Keyword: | Fisicoquímica y química teórica, Química farmacéutica, Cetoprofeno, Coeficiente de partición, Liposomas |
| Keyword: | Chemistry, Medicinal chemistry, Physical and theoretical chemistry, Ketoprofen, Partition coefficient, Liposomes |
| Full text: | Texto completo (Ver HTML) |
