| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313211 |
| ISSN: | 0100-4042 |
| Authors: | Canaes, Larissa S1 Fatibello-Filho, Orlando |
| Institutions: | 1Universidade Federal de Sao Carlos, Departamento de Quimica, Sao Carlos, Sao Paulo. Brasil |
| Year: | 2006 |
| Season: | Nov |
| Volumen: | 29 |
| Number: | 6 |
| Pages: | 1237-1240 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | A flow injection turbidimetric procedure exploiting merging zones is proposed for determining homatropine methylbromide (HMB) in pharmaceutical preparations. The determination is based on the precipitation reaction of homatropine methylbromide with AgNO3 solution to form a precipitate, which was measured at 410 nm. The analytical curve was linear in the HMB concentration range from 8.0x10-4 to 1.7x10-3 mol L-1, with a detection limit of 9.5x10-5 mol L-1. The recoveries ranged from 94.9 to 104 %, the sampling frequency was 75 h-1 and relative standard deviations were smaller than 2.0 % for solutions containing 1.2x10-3 and 1.5x10-3 mol L-1 HMB (n=10). The results obtained for commercial formulations using the FIA procedure were in good agreement with those obtained by using a comparative method (r= 0.9983) |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Formulaciones farmacéuticas, Metilbromuro de homatropina, Análisis de inyección en flujo, Turbidimetría |
| Keyword: | Chemistry, Medicinal chemistry, Pharmaceutical formulations, Homatropine methylbromide, Flow injection analysis, Turbidimetry |
| Full text: | Texto completo (Ver HTML) |
