| Journal: | Quimica nova |
| Database: | PERIÓDICA |
| System number: | 000313254 |
| ISSN: | 0100-4042 |
| Authors: | Silva, Gisele Rodrigues da1 Lages, Gustavo Portela Pianetti, Gerson Antonio Nunan, Elziria de Aguiar Soares, Cristina Duarte Vianna Campos, Ligia Maria Moreira de |
| Institutions: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil |
| Year: | 2006 |
| Season: | Nov |
| Volumen: | 29 |
| Number: | 6 |
| Pages: | 1159-1163 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | A high performance liquid chromatography method was developed to quantify lamivudine, stavudine and nevirapine combined in tablets. The separation was carried out in less than 10 min using a phosphate buffer of pH 3.0 and acetonitrile (75:25, v/v) as mobile phase, a LiChrospher ODS column and UV detection at 266 nm. The method was linear over the range of 15-135 µg/mL (lamivudine), 4-36 µg/mL (stavudine) and 20-180 µg/mL (nevirapine). The accuracy ranged from 98.56 to 102.04% and intra-day and inter-day precision was less than 1% for the three drugs. The method showed robustness, remaining unaffected by deliberate variations in relevant parameters |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Antirretrovirales, Lamivudina, Estavudina, Nevirapina, Tabletas, Validación, Cromatografía líquida de alta resolución (HPLC) |
| Keyword: | Chemistry, Medicinal chemistry, Antiretrovirals, Lamivudine, Stavudine, Nevirapine, Tablets, Validation, High performance liquid chromatography (HPLC) |
| Full text: | Texto completo (Ver HTML) |
