Atividades larvicida e anticolinesterásica de plantas do gênero Kalanchoe
Document title: Atividades larvicida e anticolinesterásica de plantas do gênero Kalanchoe
Journal: Quimica nova
Database: PERIÓDICA
System number: 000313366
ISSN: 0100-4042
Authors: 1



2
3
Institutions: 1Universidade Federal do Ceara, Departamento de Quimica Organica e Inorganica, Fortaleza, Ceara. Brasil
2Amsterdam Center for Drug Research, Division of Pharmacognosy, Leiden, Leiden, Zuid Holland. Holanda
3Universidade Estadual do Norte Fluminense, Centro de Ciencia e Tecnologia, Campos dos Goytacazes, Rio de Janeiro. Brasil
Year:
Season: Jun
Volumen: 29
Number: 3
Pages: 415-418
Country: Brasil
Language: Portugués
Document type: Artículo
Approach: Experimental, aplicado
English abstract Acetylcholine esterase inhibitors are successfully used to treat the symptoms of Alzheimer's disease. Extracts of three Kalanchoe species (K. brasiliensis, K. pinnata and K. gastonis-bornieri) showed acetylcholine esterase inhibitory effects and a toxic effect on Aedes aegypti larvae. Here we describe the bioassay guided fractionation of extracts of the most active extracts (K. brasiliensis) which resulted in the isolation of an active mixture of three flavonoids: 8-methoxyquercetin, 3,7-di-O-rhamnopyranoside and 8-methoxykaempferol-3,7-di-O-rhamnopyranoside. On TLC these flavonoids showed an acetylcholine esterase inhibitory effect
Disciplines: Química
Keyword: Fitoquímica,
Plantas medicinales,
Glucósidos flavonoles,
Actividad larvicida,
Inhibidores enzimáticos,
Acetilcolinesterasa,
Enfermedad de Alzheimer,
Kalanchoe brasiliensis,
Kalanchoe pinnata,
Kalanchoe gastonis-bornieri,
Crassulaceae
Keyword: Chemistry,
Phytochemistry,
Medicinal plants,
Flavonol glycosides,
Larvicidal activity,
Enzymatic inhibitors,
Acetylcholinesterase,
Alzheimer disease,
Kalanchoe brasiliensis,
Kalanchoe pinnata,
Kalanchoe gastonis-bornieri,
Crassulaceae
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