| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000452431 |
| ISSN: | 0074-0276 |
| Authors: | Waghabi, Mariana Caldas1 Ferreira, Roberto Rodrigues1 Abreu, Rayane da Silva1 Degrave, Wim1 Souza, Elen Mello de1 Bailly, Sabine2 Feige, Jean Jacques2 Araújo Jorge, Tania C. de1 |
| Institutions: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Institut National de la Sante et de la Recherche Medicale, Biology of Cancer and Infection Laboratory, Grenoble, Isere. Francia |
| Year: | 2022 |
| Volumen: | 117 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, prospectivo |
| English abstract | Transforming growth factor beta (TGF-β) is deeply involved on the pathogenesis of Chagas disease. Our group has been investigating the participation of this pleiotropic cytokine in different aspects of Chagas disease over the last 20 years. Important observations have been made, such as: (i) the ability of Trypanosoma cruzi in activating latent TGF-β; (ii) the potential involvement of TGF-β pathway on T. cruzi invasion of host cells; (iii) association of TGF-β with parasite intracellular replication; (iv) cardiac fibrosis development and maintenance; (v) disruption of Connexin-43 plaque structures and (vi) inflammation and immune response. In this perspective article we intend to discuss the advances of the potential use of new therapies targeting TGF-β to treat the cardiac alterations of Chagas disease-affected patients |
| Disciplines: | Medicina |
| Keyword: | Parasitología, Sistema cardiovascular, Enfermedad de Chagas, Daño cardiaco, Blancos terapéuticos, Factor de crecimiento transformante |
| Keyword: | Parasitology, Cardiovascular system, Transforming growth factor, Chagas disease, Heart damage, Therapeutic targets |
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