Single nucleotide polymorphisms in the interferon gamma gene are associated with distinct types of retinochoroidal scar lesions presumably caused by Toxoplasma gondii infection
Document title: Single nucleotide polymorphisms in the interferon gamma gene are associated with distinct types of retinochoroidal scar lesions presumably caused by Toxoplasma gondii infection
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000370983
ISSN: 0074-0276
Authors: 1
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1
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2
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Institutions: 1Universidade Estadual do Norte Fluminense, Centro de Biociencias e Biotecnologia, Campos dos Goytacazes, Rio de Janeiro. Brasil
2Universidade Federal do Parana, Departamento de Genetica, Curitiba, Parana. Brasil
Year:
Season: Feb
Volumen: 109
Number: 1
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract The association of single nucleotide polymorphisms (SNPs) in the interferon (IFN)-γ gene ( IFNG ) with different types of retinal scar lesions presumably caused by toxoplasmosis were investigated in a cross-sectional population-based genetic study. Ten SNPs were investigated and after Bonferroni correction, only the associations between SNPs rs2069718 and rs3181035 with retinal/retinochoroidal scar lesions type A (most severe scar lesions) and C (least severe scar lesions), respectively, remained significant. The associations of two different IFNG SNPs with two different types of retinal lesions attributable to toxoplasmosis support the hypothesis that different inflammatory mechanisms underlie the development of these lesions. The in vitro analysis of IFN-γ secretion by peripheral blood mononuclear cells stimulated with Toxoplasma gondii antigens was also investigated. The association between SNP rs2069718 and type A scar lesions revealed that differential IFN-γ levels are correlated with distinct genotypes. However, no correlation was observed with IFN-γ secretion levels and the SNP rs3181035 , which was significantly associated with type C scar lesions. Our findings strongly suggest that immunogenetic studies of individuals with congenital or postnatally acquired infection are needed to better understand the role of IFN-γ and its polymorphisms in the pathogenesis of ocular toxoplasmosis
Disciplines: Medicina
Keyword: Microbiología,
Parasitología,
Uveítis,
Retinocoroiditis,
Polimorfismo genético,
Toxoplasma gondii
Keyword: Medicine,
Microbiology,
Parasitology,
Uveitis,
Retinochoroiditis,
Genetic polymorphism,
Toxoplasma gondii
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