Prevalence and genetic characterisation of HTLV-1 and 2 dual infections in patients with pulmonary tuberculosis in Central-West Brazil
Document title: Prevalence and genetic characterisation of HTLV-1 and 2 dual infections in patients with pulmonary tuberculosis in Central-West Brazil
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000370986
ISSN: 0074-0276
Authors: 1
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2
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3
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Institutions: 1Universidade Federal de Goias, Instituto de Patologia Tropical e Saude Publica, Goiania, Goias. Brasil
2Universidade Federal de Goias, Faculdade de Enfermagem, Goiania, Goias. Brasil
3Instituto Oswaldo Cruz, Rio de Janeiro. Brasil
Year:
Season: Feb
Volumen: 109
Number: 1
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Human T-cell lymphotropic virus (HTLV) may impact the clinical course of tuberculosis (TB). Both infections are highly endemic in Brazil. The aim of this study was to assess the prevalence of HTLV-1/2 in TB patients in Central-West Brazil and to perform a genetic characterisation of the respective isolates. Of the 402 patients, six (1.49%) were positive for anti-HTLV and five (1.24%; 95% confidence interval: 0.46-3.05) were infected with HTLV-1/2. Genetic characterisation demonstrated that the four HTLV-1 isolates belonged to the Transcontinental subgroup A of the Cosmopolitan subtype a and that the HTLV-2 isolate belonged to subtype a (HTLV-2a/c). The prevalence of HTLV infection observed in this study is higher than that observed in local blood donors and the HTLV-1 and 2 subtypes identified are consistent with those circulating in Brazil
Disciplines: Medicina
Keyword: Microbiología,
Inmunología,
Virus linfotrópico de células T humano,
Prevalencia,
Tuberculosis,
Caracterización genética
Keyword: Medicine,
Microbiology,
Immunology,
Human T-cells lymphotropic virus,
Prevalence,
Tuberculosis,
Genetic characterization
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