| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000452402 |
| ISSN: | 0074-0276 |
| Authors: | Monteiro, Wuelton1 Karl, Stephan2 Kuehn, Andrea3 Almeida, Anne1 White, Michael2 Vitor Silva, Sheila1 Melo, Gisely1 Brito Sousa, Jose Diego1 Baia da Silva, Djane Clarys1 Silva Neto, Alexandre Vilhena1 Sampaio, Vanderson1 Bassat, Quique3 Felger, Ingrid4 Mueller, Ivo2 Lacerda, Marcus1 |
| Institutions: | 1Fundacao de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas. Brasil 2Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria. Australia 3Universidad de Barcelona, Instituto Catalán de Salud Global, Barcelona. España 4Swiss Tropical and Public Health Institute, Basilea. Suiza |
| Year: | 2022 |
| Volumen: | 117 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | BACKGROUND Understanding the epidemiology of malaria through the molecular force of the blood-stage infection of Plasmodium vivax (molFOB) may provide a detailed assessment of malaria transmission. OBJECTIVES In this study, we investigated risk factors and spatial-temporal patterns of incidence of Plasmodium infection and clinical malaria episodes in three peri-urban communities of Manaus, Western Brazilian Amazon. METHODS Monthly samples were collected in a cohort of 1,274 individuals between April 2013 and March 2014. DNA samples were subject to Plasmodium species. molFOB was calculated by counting the number of genotypes observed on each visit, which had not been present in the preceding two visits and adjusting these counts by the respective times-at-risk. FINDINGS Respectively, 77.8% and 97.2% of the population remained free of P. vivax and P. falciparum infection. Expected heterozygosity for P. vivax was 0.69 for MSP1_F3 and 0.86 for MS2. Multiplicity of infection in P. vivax was close to the value of 1. The season was associated with P. vivax positivity [adjusted hazard ratio (aHR) 2.6 (1.9-5.7)] and clinical disease [aHR 10.6 (2.4-47.2)]. P. falciparum infection was associated with previous malarial episodes [HR 9.7 (4.5-20.9)]. Subjects who reported possession of a bed net [incidence rate ratio (IRR) 1.6 (1.2-2.2)] or previous malaria episodes [IRR 3.0 (2.0-4.5)] were found to have significantly higher P. vivax molFOB. MAIN CONCLUSIONS Overall, P. vivax infection prevailed in the area and infections were mostly observed as monoclonal. Previous malaria episodes were associated with significantly higher P. vivax molFOB |
| Disciplines: | Medicina |
| Keyword: | Medicina, Parasitología, Paludismo, Mecanismos de transmisión, Carga de enfermedad, Plasmodium vivax |
| Keyword: | Parasitology, Malaria, Transmission mechanisms, Disease burden, Plasmodium vivax |
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