Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole
Document title: Pharmacokinetic and pharmacodynamic responses in adult patients with Chagas disease treated with a new formulation of benznidazole
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000391447
ISSN: 0074-0276
Authors: 1
2
3
2
3
4
1
4
Institutions: 1Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben", Buenos Aires. Argentina
2Universidad Nacional de La Plata, Facultad de Ciencias Exactas, La Plata, Buenos Aires. Argentina
3Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Laboratorio de Biología Molecular de la Enfermedad de Chagas, Buenos Aires. Argentina
4Hospital de Niños Ricardo Gutiérrez, Servicio de Parasitología-Chagas, Buenos Aires. Argentina
Year:
Season: Mar
Volumen: 111
Number: 3
Pages: 218-221
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children in all stages, but it is controversial in chronically infected adults. We report the pharmacokinetics and pharmacodynamics in six adult patients with Chagas disease treated with the new BNZ formulation (ABARAX®) in doses between 2.5-5.5 mg/Kg/day. All but one patient had plasmatic BNZ concentrations within the expected range. All patients finalised treatment with nondetectable Trypanosoma cruziquantitative polymerase chain reaction, which remained nondetectable at the six month follow-up. Our data suggests parasitological responses with the new BNZ and supports the hypothesis that treatment protocols with lower BNZ doses may be effective
Disciplines: Medicina
Keyword: Farmacología,
Enfermedad de Chagas,
Benznidazol,
Adultos,
Farmacocinética,
Farmacodinamia
Keyword: Medicine,
Pharmacology,
Chagas disease,
Benznidazole,
Adults,
Pharmacokinetics,
Pharmacodynamics
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