| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000413850 |
| ISSN: | 0074-0276 |
| Authors: | Man, Adrian1 Ciurea, Cristina Nicoleta1 Pasaroiu, Dan1 Savin, Ana Ioana1 Toma, Felicia1 Sular, Floredana2 Santacroce, Luigi3 Mare, Anca1 |
| Institutions: | 1University of Medicine and Pharmacy, Department of Microbiology, Tirgu Mures. Rumania 2University of Medicine and Pharmacy, Department of Laboratory Medicine, Tirgu Mures. Rumania 3Universita di Bari, Ospedale Policlinico Universitario, Bari, Puglia. Italia |
| Year: | 2017 |
| Season: | Sep |
| Volumen: | 112 |
| Number: | 9 |
| Pages: | 587-592 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated. OBJECTIVES The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients. METHODS The effects of different concentrations of glucose and fructose (1000 mg%, 500 mg%, 250 mg% and 100 mg% w/v) on the growth rate of CA have been studied by flow-cytometry. FINDINGS We found that glucose concentration is directly related to CA growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients; we also show that fructose inhibits CA growth rate. MAIN CONCLUSIONS As a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites |
| Disciplines: | Medicina |
| Keyword: | Endocrinología, Microbiología, Diabetes, Infecciones concurrentes, Control glucémico, Fructosa, Candida albicans |
| Keyword: | Medicine, Endocrinology, Microbiology, Diabetes, Concurrent infections, Glycemic control, Fructose, Candida albicans |
| Full text: | Texto completo (Ver HTML) |
