Intravenous whole blood transfusion results in faster recovery of vascular integrity and increased survival in experimental cerebral malaria
Document title: Intravenous whole blood transfusion results in faster recovery of vascular integrity and increased survival in experimental cerebral malaria
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000452369
ISSN: 0074-0276
Authors: 1
2
1
1
Institutions: 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil
2National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rockville, Maryland. Estados Unidos de América
Year:
Volumen: 117
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Cerebral malaria is a lethal complication of Plasmodium falciparum infections in need of better therapies. Previous work in murine experimental cerebral malaria (ECM) indicated that the combination of artemether plus intraperitoneal whole blood improved vascular integrity and increased survival compared to artemether alone. However, the effects of blood or plasma transfusion administered via the intravenous route have not previously been evaluated in ECM. OBJECTIVES To evaluate the effects of intravenous whole blood compared to intravenous plasma on hematological parameters, vascular integrity, and survival in artemether-treated ECM. METHODS Mice with late-stage ECM received artemether alone or in combination with whole blood or plasma administered via the jugular vein. The outcome measures were hematocrit and platelets; plasma angiopoietin 1, angiopoietin 2, and haptoglobin; blood-brain barrier permeability; and survival. FINDINGS Survival increased from 54% with artemether alone to 90% with the combination of artemether and intravenous whole blood. Intravenous plasma lowered survival to 18%. Intravenous transfusion provided fast and pronounced recoveries of hematocrit, platelets, angiopoietins levels and blood brain barrier integrity. MAIN CONCLUSIONS The outcome of artemether-treated ECM was improved by intravenous whole blood but worsened by intravenous plasma. Compared to prior studies of transfusion via the intraperitoneal route, intravenous administration was more efficacious
Disciplines: Medicina
Keyword: Parasitología,
Sistema cardiovascular,
Paludismo,
Infección experimental,
Cerebro,
Transfusión sanguínea,
Artemeter,
Terapia complementaria,
Disfunción endotelial
Keyword: Parasitology,
Cardiovascular system,
Malaria,
Experimental infection,
Brain,
Blood transfusion,
Artemether,
Adjunctive therapy,
Endothelial dysfunction
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