| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000392331 |
| ISSN: | 0074-0276 |
| Authors: | Cardoso, Cristina Padre1 Oliveira, Argenil Jose de Assis de2 Botoni, Fernando Antonio2 Rezende, Isabela Cristina Porto3 Alves-Filho, Jose Carlos4 Cunha, Fernando de Queiroz4 Estanislau, Juliana de Assis Silva Gomes3 Magno, Luiz Alexandre Viana5 Rios-Santos, Fabricio6 |
| Institutions: | 1Universidade Estadual de Santa Cruz, Laboratorio de Farmacogenomica e Epidemiologia Molecular, Ilheus, Bahia. Brasil 2Hospital Risoleta Tolentino Neves, Belo Horizonte, Minas Gerais. Brasil 3Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 4Universidade de Sao Paulo, Escola de Medicina, Ribeirao Preto, Sao Paulo. Brasil 5Universidade Federal de Minas Gerais, Instituto Nacional de Ciencia e Tecnologia de Medicina Molecular, Belo Horizonte, Minas Gerais. Brasil 6Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiaba, Mato Grosso. Brasil |
| Year: | 2015 |
| Season: | Jun |
| Volumen: | 110 |
| Number: | 4 |
| Pages: | 453-460 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Despite major improvements in its treatment and diagnosis, sepsis is still a leading cause of death and admittance to the intensive care unit (ICU). Failure to identify patients at high risk of developing septic shock contributes to an increase in the sepsis burden and rapid molecular tests are currently the most promising avenue to aid in patient risk determination and therapeutic anticipation. The primary goal of this study was to evaluate the genetic susceptibility that affects sepsis outcome in 72 sepsis patients admitted to the ICU. Seven polymorphisms were genotyped in key inflammatory response genes in sepsis, including tumour necrosis factor-α,interlelukin (IL)-1β, IL-10,IL-8, Toll-like receptor 4, CXCR1and CXCR2. The primary finding showed that patients who were homozygous for the major A allele in IL-10 rs1800896 had almost five times higher chance to develop septic shock compared to heterozygotes. Similarly, selected clinical features and CXCR2rs1126579 single nucleotide polymorphisms modulated septic shock susceptibility without affecting survival. These data support the hypothesis that molecular testing has clinical usefulness to improve sepsis prognostic models. Therefore, enrichment of the ICU portfolio by including these biomarkers will aid in the early identification of sepsis patients who may develop septic shock |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Microbiología, Choque séptico, Biomarcadores, Inflamación, Polimorfismo genético, Predisposición genética, Interleucina 10 |
| Keyword: | Medicine, Diagnosis, Microbiology, Septic shock, Biomarkers, Inflammation, Genetic polymorphism, Genetic predisposition, Interleukin 10 |
| Full text: | Texto completo (Ver HTML) |
