| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000452418 |
| ISSN: | 0074-0276 |
| Authors: | Andrade-Neto, Valter Viana1 Manso, Pedro Paulo de Abreu1 Pereira, Miria Gomes2 de Cicco, Nuccia Nicole Theodoro3 Atella, Georgia Corrêa3 Pelajo Machado, Marcelo1 Menna Barreto, Rubem Figueiredo Sadok1 Torres Santos, Eduardo Caio1 |
| Institutions: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Universidade Federal do Rio de Janeiro, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro. Brasil 3Universidade Federal do Rio de Janeiro, Instituto de Bioquimica Medica, Rio de Janeiro. Brasil |
| Year: | 2022 |
| Volumen: | 117 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | A significant percentage of exogenous cholesterol was found in promastigotes and amastigotes of all studied species of Leishmania, suggesting a biological role for this molecule. Previous studies have shown that promastigotes of Leishmania uptake more low-density lipoprotein (LDL) particles under pharmacological pressure and are more susceptible to ergosterol inhibition in the absence of exogenous sources of cholesterol. This work shows that the host’s LDL is available to intracellular amastigotes and that the absence of exogenous cholesterol enhances the potency of sterol biosynthesis inhibitors in infected macrophages. A complete understanding of cholesterol transport to the parasitophorous vacuole can guide the development of a new drug class to be used in combination with sterol biosynthesis inhibitors for the treatment of leishmaniases |
| Disciplines: | Medicina |
| Keyword: | Metabolismo y nutrición, Parasitología, Leishmaniasis, Colesterol, Inhibidores biosintéticos |
| Keyword: | Metabolism and nutrition, Parasitology, Leishmaniasis, Cholesterol, Biosynthetic inhibitors |
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