| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000452415 |
| ISSN: | 0074-0276 |
| Authors: | de Azevedo, Sophia Lincoln Cardoso1 Catanho, Marcos1 Guimarães, Ana Carolina Ramos1 Galvão, Teca Calcagno1 |
| Institutions: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil |
| Year: | 2022 |
| Volumen: | 117 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, prospectivo |
| English abstract | Chagas disease is an enduring public health issue in many Latin American countries, receiving insufficient investment in research and development. Strategies for disease control and management currently lack efficient pharmaceuticals, commercial diagnostic kits with improved sensitivity, and vaccines. Genetic heterogeneity of Trypanosoma cruzi is a key aspect for novel drug design since pharmacological technologies rely on the degree of conservation of parasite target proteins. Therefore, there is a need to expand the knowledge regarding parasite genetics which, if fulfilled, could leverage Chagas disease research and development, and improve disease control strategies. The growing capacity of whole-genome sequencing technology and its adoption as disease surveillance routine may be key for solving this long-lasting problem |
| Disciplines: | Medicina |
| Keyword: | Parasitología, Genética, Enfermedad de Chagas, Secuencia genómica, Variación genética, Fármacos tripanosomicidas, Trypanosoma cruzi, Biología computacional |
| Keyword: | Parasitology, Genetics, Chagas disease, Genomic sequence, Genetic variation, Trypanocidal drugs, Trypanosoma cruzi, Computational biology |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
