Fast surveillance response reveals the introduction of a new yellow fever virus sub-lineage in 2021, in Minas Gerais, Brazil
Document title: Fast surveillance response reveals the introduction of a new yellow fever virus sub-lineage in 2021, in Minas Gerais, Brazil
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000452377
ISSN: 0074-0276
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Institutions: 1Universidade de Brasilia, Instituto de Ciencias Biologicas, Brasilia, Distrito Federal. Brasil
2Universidade Federal do Tocantins, Laboratorio de Bioinformatica e Biotecnologia, Gurupi, Tocantins. Brasil
3Universidade Federal do Rio Grande do Sul, Instituto de Ciencias Basicas da Saude, Porto Alegre, Rio Grande do Sul. Brasil
4Instituto Federal do Norte de Minas Gerais, Laboratorio de Comportamento de Insetos, Salinas, Minas Gerais. Brasil
5Secretaria Estadual da Saude do Rio Grande do Sul, Centro Estadual de Vigilancia em Saude, Porto Alegre, Rio Grande do Sul. Brasil
6Organizacao Pan-Americana da Saude, Brasilia, Distrito Federal. Brasil
7Universidade Estadual de Santa Cruz, Departamento de Agricultura e Ciencias Ambientais, Ilheus, Bahia. Brasil
8Secretaria de Saude do Estado de Minas Gerais, Coordenacao Estadual de Vigilancia de Arbovírus, Belo Horizonte, Minas Gerais. Brasil
9Fundacao Ezequiel Dias, Laboratorio Central de Saude Publica, Belo Horizonte, Minas Gerais. Brasil
10Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil
11Ministerio da Saude, Coordenacao Geral de Vigilancia de Arbovírus, Brasilia, Distrito Federal. Brasil
Year:
Volumen: 117
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract In Brazil, the yellow fever virus (YFV) is maintained in a sylvatic cycle involving wild mosquitoes and non-human primates (NHPs). The virus is endemic to the Amazon region; however, waves of epidemic expansion reaching other Brazilian states sporadically occur, eventually causing spillovers to humans. OBJECTIVES To report a surveillance effort that led to the first confirmation of YFV in NHPs in the state of Minas Gerais (MG), Southeast region, in 2021. METHODS A surveillance network was created, encompassing the technology of smartphone applications and coordinated actions of several research institutions and health services to monitor and investigate NHP epizootics. FINDINGS When alerts were spread through the network, samples from NHPs were collected and YFV infection confirmed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and genome sequencing at an interval of only 10 days. Near-complete genomes were generated using the Nanopore MinION sequencer. Phylogenetic analysis indicated that viral genomes were related to the South American genotype I, clustering with a genome detected in the Amazon region (state of Pará) in 2017, named YFVPA/MG sub-lineage. Fast YFV confirmation potentialised vaccination campaigns. MAIN CONCLUSIONS A new YFV introduction was detected in MG 6 years after the beginning of the major outbreak reported in the state (2015-2018). The YFV strain was not related to the sub-lineages previously reported in MG. No human cases have been reported, suggesting the importance of coordinated surveillance of NHPs using available technologies and supporting laboratories to ensure a quick response and implementation of contingency measures to avoid YFV spillover to humans
Disciplines: Medicina
Keyword: Virus,
Epidemiología,
Fiebre amarilla,
Arbovirus,
Flavivirus,
Epizootia,
Control de vectores
Keyword: Virus,
Epidemiology,
Yellow fever,
Arbovirus,
Flavivirus,
Epizooty,
Vector control
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