| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000420039 |
| ISSN: | 0074-0276 |
| Authors: | Mann, Danielle1 Sant’Anna, Flávia Marinho1 Schmaltz, Carolina Arana Stanis1 Freitas, Dayvison Francis Saraiva1 Rolla, Valeria Cavalcanti1 Cavalcante, Solange Cesar1 Gutierrez-Galhardo, Maria Clara1 |
| Institutions: | 1Fundacao Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro. Brasil |
| Year: | 2018 |
| Volumen: | 113 |
| Number: | 9 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Cutaneous tuberculosis (CTB) is a rare extrapulmonary form of tuberculosis (TB). Despite the increase in the number of cases of TB and HIV, few cases of CTB have been reported. OBJECTIVE To describe CTB cases among patients with HIV infection from a cohort with tuberculosis. METHODS We describe a series of 15 CTB and HIV cases, based on secondary data from 2000 to 2016. Diagnosis was based on isolation of Mycobacterium tuberculosis in culture or clinical response to anti-tuberculous treatment associated with positive smear or histopathologic findings from affected skin or an adjacent lymph node. FINDINGS Scrofuloderma was present in 12 (80%) patients and solitary gumma in three (20%) patients. One case of scrofuloderma was associated with papulonecrotic tuberculid. Seven (46.6%) patients had pulmonary TB. Diagnosis was based on culture in nine patients (60%). The median CD4 cell count was 262 cells/µL. All patients were cured at the end of treatment (median time 6 months). Three patients presented with immune reconstitution inflammatory syndrome. CONCLUSIONS In this study, CTB associated with HIV infection presented as localised forms or in association with pulmonary TB. In patients with HIV who have subacute and chronic skin lesions, CTB should be considered in differential diagnosis, which may represent a good opportunity for early diagnosis of active TB |
| Disciplines: | Medicina |
| Keyword: | Inmunología, Microbiología, VIH, Tuberculosis cutánea, Coinfecciones, Síndrome inflamatorio de reconstitución inmune, Mycobacterium tuberculosis |
| Keyword: | Immunology, Microbiology, HIV, Cutaneous tuberculosis, Coinfections, Immune reconstitution inflammatory syndrome, Mycobacterium tuberculosis |
| Full text: | Texto completo (Ver HTML) |
