| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000452371 |
| ISSN: | 0074-0276 |
| Authors: | Monteiro, Fernanda Pereira1 Tavares, Victor de Souza1 Souza, Rayane da Silva Oliveira1 Venâncio, Larissa Paola Rodrigues1 Fabres Klein, Mary Hellen1 do Carmo, Rodrigo Feliciano2 Klein, Raphael Contelli1 Lima, Jonilson Berlink1 Araújo Santos, Théo1 |
| Institutions: | 1Universidade Federal da Bahia, Centro das Ciencias Biologicas e da Saude, Barreiras, Bahia. Brasil 2Universidade Federal do Vale do Sao Francisco, Colegiado de Ciencias Farmaceuticas, Petrolina, Pernambuco. Brasil |
| Year: | 2022 |
| Volumen: | 117 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Patients with severe coronavirus disease 2019 (COVID-19) often present with coagulopathies and have high titres of circulating antibodies against viral proteins. OBJECTIVES Herein, we evaluated the association between D-dimer and circulating immunoglobulin levels against viral proteins in patients at different clinical stages of COVID-19. METHODS For this, we performed a cross-sectional study involving patients of the first wave of COVID-19 clinically classified as oligosymptomatic (n = 22), severe (n = 30), cured (n = 27) and non-infected (n = 9). Next, we measured in the plasma samples the total and fraction of immunoglobulins against the nucleoprotein (NP) and the receptor-binding domain (RBD) of the spike proteins by enzyme-linked immunosorbent assay (ELISA) assays. FINDINGS Patients with severe disease had a coagulation disorder with high levels of D-dimer as well as circulating IgG against the NP but not the RBD compared to other groups of patients. In addition, high levels of D-dimer and IgG against the NP and RBD were associated with disease severity among the patients in this study. MAIN CONCLUSIONS Our data suggest that IgG against NP and RBD participates in the worsening of COVID-19. Although the humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is partially understood, and more efforts are needed to clarify gaps in the knowledge of this process |
| Disciplines: | Medicina |
| Keyword: | Hematología, Inmunología, COVID-19, SARS-CoV-2, Coagulopatía, Respuesta humoral, Proteínas virales |
| Keyword: | Hematology, Immunology, COVID-19, SARS-CoV-2, Coagulopathy, Humoral response, Viral proteins |
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