Co-infections associated with human immunodeficiency virus type 1 in pregnant women from southern Brazil: high rate of intraepithelial cervical lesions
Document title: Co-infections associated with human immunodeficiency virus type 1 in pregnant women from southern Brazil: high rate of intraepithelial cervical lesions
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000349683
ISSN: 0074-0276
Authors: 1
1
1
2
1
2
2
1
Institutions: 1Universidade Federal do Rio Grande, Faculdade de Medicina, Rio Grande, Rio Grande do Sul. Brasil
2Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Rio de Janeiro. Brasil
Year:
Season: Mar
Volumen: 107
Number: 2
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Human immunodeficiency virus type 1 (HIV-positive) pregnant women require specific prophylactic and therapeutic approaches. The efficacy of established approaches is further challenged by co-infection with other sexually transmitted diseases (STDs). The objective of this study was to determine the prevalence of co-infections in pregnant women infected with different HIV-1 subtypes and to relate these findings, together with additional demographic and clinical parameters, to maternal and infant outcomes. Blood samples from pregnant women were collected and tested for syphilis, hepatitis B virus (HBV) and hepatitis C virus (HCV). Human papillomavirus (HPV) diagnosis was evaluated by the presence of alterations in the cervical epithelium detected through a cytopathological exam. Medical charts provided patient data for the mothers and children. Statistical analyses were conducted with STATA 9.0. We found a prevalence of 10.8% for HCV, 2.3% for chronic HBV, 3.1% for syphilis and 40.8% for HPV. Of those co-infected with HPV, 52.9% presented high-grade intraepithelial lesions or in situ carcinoma. Prematurity, birth weight, Apgar 1' and 5' and Capurro scores were similar between co-infected and non-co-infected women. The presence of other STDs did not impact maternal and concept outcomes. More than half of the patients presenting cervical cytology abnormalities suggestive of HPV had high-grade squamous intraepithelial lesions or cervical cancer, evidencing an alarming rate of these lesions
Disciplines: Medicina
Keyword: Oncología,
Ginecología,
Embarazo,
VIH,
Coinfecciones,
Carcinoma cervical
Keyword: Medicine,
Oncology,
Gynecology,
Pregnancy,
HIV,
Coinfections,
Cervical carcinoma
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