CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
Document title: CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000437040
ISSN: 0074-0276
Authors: 1
2
3
4
4
5
2
4
Institutions: 1Universidade Federal de Vicosa, Florestal, Minas Gerais. Brasil
2Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, Minas Gerais. Brasil
3Pontificia Universidade Catolica de Minas Gerais, Faculdade de Odontologia, Belo Horizonte, Minas Gerais. Brasil
4Universidade Federal de Minas Gerais, Departamento de Morfologia, Belo Horizonte, Minas Gerais. Brasil
5Centro de Cancer A.C. Camargo, Sao Paulo. Brasil
6Instituto Nacional de Ciencia e Tecnologia de Doencas Tropicais, Salvador, Bahia. Brasil
Year:
Volumen: 115
Country: Brasil
Language: Inglés
Document type: Nota breve o noticia
Approach: Experimental, aplicado
English abstract We aimed to investigate the association of CD14 -260C/T (rs2569190) polymorphism and Chagas cardiomyopathy and the functional characteristics of CD14+ and CD14- monocytes upon infection with Trypanosoma cruzi. We observed an association between the T- genotype (absence of allele -260T) related to low CD14 expression and the dilated cardiomyopathy type of Chagas disease. Furthermore, we observed that CD14- monocytes showed a more activated profile upon in vitro infection with T. cruzi than CD14+ monocytes. Our findings suggest that T- genotype is associated with susceptibility to develop Chagas dilated cardiomyopathy, likely linked to the T. cruzi-induced inflammatory profile of CD14- monocytes
Disciplines: Medicina
Keyword: Genética,
Inmunología,
Cardiomiopatia chagásica,
CD14,
Polimorfismo genético,
Respuesta inmune
Keyword: Genetics,
Immunology,
Immune response,
Chagas cardiomyopathy,
CD14,
Genetic polymorphism
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