| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000372690 |
| ISSN: | 0074-0276 |
| Authors: | Dunder, Ricardo Jose1 Luiz-Ferreira, Anderson1 Almeida, Ana Cristina Alves de1 Faria, Felipe Meira de1 Takayama, Christiane1 Socca, Eduardo Augusto Rabelo1 Salvador, Marcos Jose2 Mello, Glaucia Coelho1 Santos, Catarina dos3 Oliva-Neto, Pedro de3 Souza-Brito, Alba Regina Monteiro1 |
| Institutions: | 1Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, Sao Paulo. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biologia, Jaboticabal, Sao Paulo. Brasil 3Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias e Letras de Assis, Assis, Sao Paulo. Brasil |
| Year: | 2013 |
| Season: | May |
| Volumen: | 108 |
| Number: | 3 |
| Pages: | 263-271 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and pleurisy) and a chronic mouse model (granuloma cotton pellet). The antinociceptive potential was evaluated in chemical (acetic-acid) and thermal (tail-flick and hot-plate test) models of pain. When given orally, HFAS (5, 10, 25 and 50 mg/kg) reduced ear oedema (p < 0.0001; 52%, 71%, 62% and 42%, respectively). HFAS also reduced hind paw oedema at doses of 10 mg/kg and 25 mg/kg (p < 0.05; 42% and 58%, respectively) and pleurisy at doses of 10 mg/kg and 25 mg/kg (41% and 50%, respectively). In a chronic model, HFAS reduced inflammation by 46% and 58% at doses of 10 mg/kg and 25 mg/kg, respectively. Moreover, this fraction showed analgesic properties against the abdominal writhing in an acetic acid model (at doses of 5-25 mg/kg) with inhibitory rates of 24%, 54% and 48%. The HFAS also showed an increased latency time in the hot-plate (23% and 28%) and tail-flick tests (61% and 66%) for the 25 mg/kg and 50 mg/kg doses, respectively. These results suggest that HFAS has anti-inflammatory and analgesic properties |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Plantas medicinales, Bioensayos, Actividad antiinflamatoria, Actividad analgésica, Hecogenina, Tigogenina, Agave sisalana |
| Keyword: | Medicine, Pharmacology, Medicinal plants, Bioassays, Antiinflammatory activity, Analgesic activity, Hecogenin, Tigogenin, Agave sisalana |
| Full text: | Texto completo (Ver HTML) |
