| Journal: | lRevista médica de Chile |
| Database: | PERIÓDICA |
| System number: | 000449453 |
| ISSN: | 0034-9887 |
| Authors: | Meza Romero, Rodrigo1 Andino, Romina1 Rojas, Patricio1 Vargas, Sebastián1 Jerez, Joaquín1 |
| Institutions: | 1Pontificia Universidad Católica de Chile, Escuela de Medicina, Santiago de Chile. Chile |
| Year: | 2021 |
| Volumen: | 149 |
| Number: | 5 |
| Pages: | 747-757 |
| Country: | Chile |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Monoclonal gammopathies of uncertain significance (MGUS) correspond to pre-malignant hematological disorders characterized by the production of a monoclonal protein and infiltration of less than 10% of the bone marrow by plasma cells. Its importance lies in the risk of progression to malignant disorders and in the association with different renal, neurological and skin manifestations. There are pathophysiological mechanisms that support a causal relationship between monoclonal gammopathies (MGs) and different skin diseases, such as type I cryoglobulinemia (CG), primary systemic amyloidosis (PSA) or necrobiotic xanthogranuloma (NXG). However, there is a group of skin diseases associated with MGs whose pathogenesis has not been elucidated. In this context, the role of the dermatologist is crucial in the suspicion of different haematological disorders based on skin manifestations and in the multidisciplinary treatment of these patients. In this article, we carry out an exhaustive review of the literature published in this area and propose a screening algorithm for MGs in patients with specific skin diseases |
| Disciplines: | Medicina |
| Keyword: | Hematología, Dermatología, Gamapatías monoclonales, Paraproteinemia, Manifestaciones cutáneas |
| Keyword: | Hematology, Dermatology, Monoclonal gammopathies, Paraproteinemia, Skin manifestations |
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