Determinación de factores de riesgo a reacciones adversas a medicamentos mediante farmacovigilancia intensiva en UCI



Document title: Determinación de factores de riesgo a reacciones adversas a medicamentos mediante farmacovigilancia intensiva en UCI
Journal: lRevista médica de Chile
Database: PERIÓDICA
System number: 000449351
ISSN: 0034-9887
Authors: 1
1
2
Institutions: 1Pontificia Universidad Católica de Chile, Facultad de Química y Farmacia, Santiago de Chile. Chile
2Pontificia Universidad Católica de Chile, Facultad de Medicina, Santiago de Chile. Chile
Year:
Volumen: 149
Number: 9
Pages: 1258-1266
Country: Chile
Language: Español
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Patients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR). Aim: To determine risk factors for ADR, through intensive pharmacological surveillance at the ICU. Patients and Methods: An observational, descriptive and prospective study was made, determining risk parameters in patients who experienced ADR. Results: Eighty-five patients were surveilled and 24 (28%) had an ADR. A total of 48 drugs responsible for at least one ADR were identified. Seventy-three percent ADR were moderate and 27% were severe. The clinical variables significantly associated with ADR were a history of allergies, a high body mass index, the reason for admission, an APACHE II score ≥ 14 points, the use of invasive mechanical ventilation and more than seven days of hospitalization. The pharmacological variables associated with ADR were polypharmacy and medication associations and combinations. Conclusions: The identified risk factors have a great impact on pharmacokinetic and pharmacodynamic parameters, and should be considered to avoid the appearance of ADR
Disciplines: Medicina
Keyword: Farmacología,
Hospitales,
Interacciones farmacológicas,
Reacciones adversas,
Polifarmacia,
Farmacovigilancia
Keyword: Pharmacology,
Hospitals,
Drug interactions,
Adverse reactions,
Polypharmacy,
Pharmacovigilance
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