| Revista: | lRevista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000449351 |
| ISSN: | 0034-9887 |
| Autores: | Obreque, Karin1 Mellado, Rosemarie1 Andresen, Max2 |
| Instituciones: | 1Pontificia Universidad Católica de Chile, Facultad de Química y Farmacia, Santiago de Chile. Chile 2Pontificia Universidad Católica de Chile, Facultad de Medicina, Santiago de Chile. Chile |
| Año: | 2021 |
| Volumen: | 149 |
| Número: | 9 |
| Paginación: | 1258-1266 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Patients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR). Aim: To determine risk factors for ADR, through intensive pharmacological surveillance at the ICU. Patients and Methods: An observational, descriptive and prospective study was made, determining risk parameters in patients who experienced ADR. Results: Eighty-five patients were surveilled and 24 (28%) had an ADR. A total of 48 drugs responsible for at least one ADR were identified. Seventy-three percent ADR were moderate and 27% were severe. The clinical variables significantly associated with ADR were a history of allergies, a high body mass index, the reason for admission, an APACHE II score ≥ 14 points, the use of invasive mechanical ventilation and more than seven days of hospitalization. The pharmacological variables associated with ADR were polypharmacy and medication associations and combinations. Conclusions: The identified risk factors have a great impact on pharmacokinetic and pharmacodynamic parameters, and should be considered to avoid the appearance of ADR |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Hospitales, Interacciones farmacológicas, Reacciones adversas, Polifarmacia, Farmacovigilancia |
| Keyword: | Pharmacology, Hospitals, Drug interactions, Adverse reactions, Polypharmacy, Pharmacovigilance |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
