| Journal: | Journal of the Mexican Chemical Society |
| Database: | PERIÓDICA |
| System number: | 000365307 |
| ISSN: | 1665-9686 |
| Authors: | Yu Lin, Hu1 Xiang, Liu1 Ming, Lu1 |
| Institutions: | 1Nanjing University of Science and Technology, Chemical Engineering College, Nanjing, Jiangsu. China |
| Year: | 2010 |
| Season: | Abr-Jun |
| Volumen: | 54 |
| Number: | 2 |
| Pages: | 74-78 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| Spanish abstract | A series of 6-substituted purines were synthesized from commercially available 2-amino-6-chloropurine with appropriate reagents, and nine new compounds 7, 8, and 11-17 have been discovered. The compounds synthesized were identified by elemental analysis, 1H NMR, as well as mass spectral data. All the title compounds were screened for their antifungal activities, under the method of the disc diffusion, using three species of fungi — Bacillus subtillis, Aspergillus niger, and Candida tropicalis— and some of the compounds showed promising activities |
| English abstract | Se preparó una serie de purinas 6-sustituidas a partir de la 2-amino-6-cloropurina, que está disponible comercialmente, y de los reactivos apropiados, de los cuales los derivados 7, 8 y 11-17 no han sido reportados previamente. Los compuestos sintetizados se caracterizaron por análisis elemental, RMN 1H y espectrometría de masas. Todos los compuestos se evaluaron en su actividad antifúngica, a través del método de difusión de discos, sobre tres especies de hongos — Bacillus subtillis, Aspergillus niger y Candida tropicalis—, mostrando algunos de ellos una actividad promisoria |
| Disciplines: | Biología, Ingeniería |
| Keyword: | Hongos, Ingeniería química, Bacillus subtilis, Aspergillus niger, Candida tropicalis, Purinas, Actividad antifúngica |
| Keyword: | Biology, Engineering, Fungi, Chemical engineering, Bacillus subtilis, Aspergillus niger, Candida tropicalis, Purines, Antifungal activity |
| Full text: | Texto completo (Ver PDF) |
