Substituted pyridopyrimidinones. Part 3: synthesis of some novel ether derivatives of 4h-pyrido[1,2-a]pyrimidin-4-one
Document title: Substituted pyridopyrimidinones. Part 3: synthesis of some novel ether derivatives of 4h-pyrido[1,2-a]pyrimidin-4-one
Journal: Journal of the Mexican Chemical Society
Database: PERIÓDICA
System number: 000373986
ISSN: 1665-9686
Authors: 1
1
1
1
Institutions: 1Ain Shams University, Department of Chemistry, El Cairo. Egipto
Year:
Season: Abr-Jun
Volumen: 53
Number: 2
Country: México
Language: Inglés
Document type: Artículo
Approach: Experimental, analítico
Spanish abstract Se preparó una serie de novedosos éteres bis–heterocíclicos que contienen el anillo de 4H–pirido[1,2–a]pirimidin–4–ona, unido con anillos heterocíclicos de seis miembros, empleando [(4–oxo–4H–pirido[1,2–a]pirimidin–2–il)oxi]acetato de etilo (1), ácido [(4–oxo–4H–pirido[1,2–a]pirimidin–2–il)oxi]acético (2) o [(4–oxo–4H–pirido[1,2–a]pirimidin–2–il)oxi]acetohidrazida (3). La reacción del éster 1 con algunos orto–hidroxi–aldehidos proporcionaron las piridopirimidiloxipironas correspondientes. La reacción del éster 1 o el ácido 2 con 1,2–diaminas condujeron a algunos imidazoles. Asimismo, se prepararon algunos derivados de pirazol, triazol y oxiadiazolina a partir de la hidrazina 3
English abstract A series of novel bis–heterocyclic ethers, containing 4H–pyrido[1,2–a]pyrimidin–4–one along with other five and six–membered heterocyclic rings, was obtained utilizing ethyl [(4–oxo–4H–pyrido[1,2–a]pyrimidin–2–yl)oxy]acetate (1), [(4–oxo–4H–pyrido[1,2–a]pyrimidin–2–yl)oxy]acetic acid (2) and/or [(4–oxo–4H–pyrido[1,2–a]pyrimidin–2–yl)oxy]acetohydrazide (3). Reaction of ester 1 with some ortho–hydroxy–aldehydes furnished the corresponding pyrido–pyrimidyloxypyrones. Reaction of ester 1 or acid 2 with 1,2–diamines led to some imidazoles. Also, some pyrazole, triazole, and oxadiazoline derivatives have been prepared from hydrazide 3
Disciplines: Química
Keyword: Química farmacéutica,
Química orgánica,
Eteres,
Pirazoles,
Oxadiazolinas,
Pironas
Keyword: Chemistry,
Medicinal chemistry,
Organic chemistry,
Ethers,
Pyrazoles,
Oxadiazolines,
Pyrones
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