Stereochemical investigation of a novel biological active substance from the secondary metabolites of marine fungus Penicillium chrysogenum SYP-F-2720
Document title: Stereochemical investigation of a novel biological active substance from the secondary metabolites of marine fungus Penicillium chrysogenum SYP-F-2720
Journal: Journal of the Mexican Chemical Society
Database: PERIÓDICA
System number: 000384156
ISSN: 1665-9686
Authors: 1
1
1
2
1
Institutions: 1Shenyang Pharmaceutical University, Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang, Liaoning. China
2Shenyang Pharmaceutical University, Pharmacy Department, Shenyang, Liaoning. China
Year:
Season: Ene-Mar
Volumen: 59
Number: 1
Country: México
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
Spanish abstract Se determinó la estructura química y la configuración absoluta de un ácido benzoico novedoso (1), presente en los metabolitos secundarios del hongo marino Penicillium chrysogenum SYP-F-2720. La determinación se llevó a cabo mediante datos espectroscópicos experimentales y cálculos químicos cuánticos de su dicroísmo circular electrónico (DCE). La asignación de la configuración se confirmó mediante la comparación de los espectros del compuesto natural y el correspondiente compuesto sintético. Además, el compuesto aislado exhibe actividades anti-inflamatorias y analgésicas más significativas que la aspirina cuando se administró a una dosis de 100 mg / kg, y no mostró ningún efecto ulcerogénico
English abstract The chemical structure and absolute configuration of a novel benzoic acid (1) which is the secondary metabolites from the marine fungus Penicillium chrysogenum SYP-F-2720, has been determined by experimental spectroscopic data and quantum chemical calculations of its electronic circular dichroism (ECD). The configurational assignments were further confirmed by the highly consistent spectra between natural compound and synthetic compound which from raw material with a definite configuration. Furthermore, The target compound exhibited more significant anti-inflammatory and analgesic activities than aspirin when administered at 100 mg/kg, however, it behaved no ulcerogenic effect
Disciplines: Biología,
Química
Keyword: Hongos,
Bioquímica,
Química farmacéutica,
Hongos marinos,
Penicillium chrysogenum,
Estereoquímica,
Metabolitos secundarios,
Acido benzoico,
Antiinflamatorios,
Analgésicos
Keyword: Biology,
Chemistry,
Fungi,
Biochemistry,
Medicinal chemistry,
Marine fungi,
Penicillium chrysogenum,
Stereochemistry,
Secondary metabolites,
Benzoic acid,
Antiinflammatory activity,
Analgesics
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