| Journal: | Journal of the Mexican Chemical Society |
| Database: | PERIÓDICA |
| System number: | 000437702 |
| ISSN: | 1870-249X |
| Authors: | Tunc, Turgay1 Demirel, Nadir2 Emir, Mahmut2 Günel, Aslıhan2 Çolak, Mehmet3 Karacan, Nurcan4 |
| Institutions: | 1Ahi Evran University, Faculty of Engineering, Kirsehir. Turquía 2Ahi Evran University, Faculty of Science and Arts, Kirsehir. Turquía 3Dicle University, Faculty of Science, Diyarbakir. Turquía 4Gazi University, Faculty of Science, Ankara. Turquía |
| Year: | 2018 |
| Season: | Jul-Sep |
| Volumen: | 62 |
| Number: | 3 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| Spanish abstract | Tres nuevos complejos de cobre (II) (1-3) con la fórmula general [Cu (HL) CH3COO] de N-salicil-β-amino alcohol Schiff bases que contienen, (S) - (+) - fenilglicinol, (1S, 2R). Se sintetizaron -2-amino-1, 2-difeniletanol y 1, 1, 3-trifenil- (R) - (+) - 2-amino propanol. Sus estructuras se caracterizaron por FTIR, LCMS, momento magnético, conductancia molar y datos de análisis elemental. Los cálculos de DFT propusieron geometrías planas cuadradas distorsionadas para los complejos. Los espectros de IR calculados están en buena concordancia con los espectros de IR experimentales, confirmando las estructuras propuestas. Se investigaron sus interacciones con el ADN del timo de ternera y se encontraron sus constantes de unión Kb. La electroforesis en gel revela que todos los complejos muestran una actividad nucleasa significativa contra el ADN plasmídico pentry / d-topo superenrollado |
| English abstract | Three new copper(II) complexes (1-3) with general formula [Cu(HL)CH3COO] of N-salicyl-β-amino alcohol Schiff bases containing, (S)-(+)-phenyl glycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and 1, 1, 3-triphenyl-(R)-(+)-2-amino propanol, were synthesized. Their structures were characterized by FTIR, LCMS, magnetic moment, molar conductance and elemental analysis data. DFT calculations proposed distorted square planar geometries for the complexes. The calculated IR spectra are in good agreement with the experimental IR spectra, confirming the proposed structures. Their interactions with calf thymus DNA were investigated and their binding constants Kb were found. Gel electrophoresis reveals that all complexes display significant nuclease activity against supercoiled pentry/d-topo plasmid DNA |
| Disciplines: | Ingeniería |
| Keyword: | Ingeniería química, Complejos de cobre (II), Teoría del funcional de la densidad (DFT), ADN, Bases de Schiff |
| Keyword: | Chemical engineering, Copper (II) complexes, Density functional theory (DFT), DNA, Schiff bases |
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