Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
Document title: Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives
Journal: Journal of the Brazilian Chemical Society
Database: PERIÓDICA
System number: 000311884
ISSN: 0103-5053
Authors: 1


2
3
Institutions: 1Universidade Federal de Juiz de Fora, Departamento de Quimica, Juiz de Fora, Minas Gerais. Brasil
2Colegio de Aplicacao Joao XXIII, Juiz de Fora, Minas Gerais. Brasil
3Free University of Brussels, Faculty of Applied Sciences, Bruselas. Bélgica
Year:
Season: Dic
Volumen: 17
Number: 7
Pages: 1266-1273
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract This work describes the synthesis and characterization of eleven new platinum(II) complexes having ligands derived from 1,2-phenylenediamine, N-benzyl ethylenediamine and 2- or 4-picoline. The complexes were prepared in satisfactory yields by reaction of K2[PtCl4] with the appropriate ligand. The cytotoxic pre-screening of one of these complexes in seven human cancer cell lines showed that this compound is much less active than cisplatin
Portuguese abstract Este trabalho descreve a síntese e a caracterização de onze novos complexos de platina(II), contendo como ligantes derivados da 1,2-fenilenodiamina, da N-benzil etilenodiamina, e da 2- ou 4-picolina. Os complexos foram preparados em rendimentos satisfatórios pela reação dos ligantes com K2[PtCl4]. É descrita também a atividade citotóxica de um dos complexos de platina(II), em sete linhagens de células tumorais de origem humana, que se mostrou muito menos ativo do que a cisplatina
Disciplines: Química,
Medicina
Keyword: Química farmacéutica,
Oncología,
Complejos de platino,
1,2-fenilendiamina,
Bencil etilendiamina,
Picolina,
Cáncer
Keyword: Chemistry,
Medicine,
Medicinal chemistry,
Oncology,
Platinum complexes,
1,2-phenylenediamine,
Benzyl ethylenediamine,
Picoline,
Cancer
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