| Journal: | Journal of the Brazilian Chemical Society |
| Database: | PERIÓDICA |
| System number: | 000311252 |
| ISSN: | 0103-5053 |
| Authors: | Makino, Shingo1 Nakanishi, Eiji Tsuji, Takashi |
| Institutions: | 1Ajinomoto Co. Pharmaceutical Company, Pharmaceutical Research Laboratories, Kawasaki, Kanagawa. Japón |
| Year: | 2003 |
| Season: | May |
| Volumen: | 14 |
| Number: | 3 |
| Pages: | 452-455 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors of 1,2,3-benzotriazin-4-ones, 2-aminobenzamides, were prepared from solid-supported amines and 2-nitrobenzoic acids. Various 1,2,3-benzotriazin-4-ones were obtained with high purity using SynPhaseTM Lanterns |
| Portuguese abstract | A síntese de 1,2,3-benzotriazin-4-onas em fase sólida através da ciclização de 2-aminobenzamidas é descrita. O desenvolvimento de um método de síntese eficiente é importante para o desenvolvimento de drogas em razão da atividade biológica variada desses compostos. Os precursores de 1,2,3-benzotriazin-4-onas, as 2-aminobenzamidas, foram preparadas a partir de aminas ligadas a suporte sólido e ácidos 2-nitrobenzóicos. Várias 1,2,3-benzotriazin-4-onas foram obtidas em alta pureza utilizando-se SynPhaseTM Lanterns." |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Síntesis en fase sólida, Quinazolina, Benzoxazinas, Diazotización |
| Keyword: | Chemistry, Medicinal chemistry, Solid-phase synthesis, Quinazoline, Benzoxazines, Diazotization |
| Full text: | Texto completo (Ver HTML) |
