Tecnica de oscilacoes forcadas na analise da resposta broncodilatadora em voluntarios sadios e individuos portadores de asma bronquica com resposta positiva



Document title: Tecnica de oscilacoes forcadas na analise da resposta broncodilatadora em voluntarios sadios e individuos portadores de asma bronquica com resposta positiva
Journal: Jornal brasileiro de pneumologia
Database: PERIÓDICA
System number: 000297601
ISSN: 1806-3713
Authors: 1


Institutions: 1Universidade do Estado do Rio de Janeiro, Rio de Janeiro. Brasil
Year:
Season: Mar-Abr
Volumen: 32
Number: 2
Pages: 91-98
Country: Brasil
Language: Portugués
Document type: Artículo
Approach: Caso clínico, analítico
English abstract OBJECTIVE: To use the forced oscillation technique to evaluate asthma patients presenting positive bronchodilator responses (confirmed through spirometry) and compare the results with those obtained in healthy individuals. METHODS: The study sample consisted of 53 non-smoking volunteers: 24 healthy subjects with no history of pulmonary disease and 29 asthmatics presenting positive bronchodilator response, as determined through analysis of spirometry findings. All of the subjects were submitted to forced oscillation technique and spirometry immediately before and 20 minutes after the administration of salbutamol spray (300 g). The parameters derived from the forced oscillation technique were total respiratory resistance, total respiratory reactance, resistance extrapolated to the y axis, the slope of resistance, and dynamic compliance. The parameters measured in the spirometry evaluation tests were forced expiratory volume in one second and forced vital capacity. RESULTS: In the control group, bronchodilator use produced a significant alteration in the resistance extrapolated to the y axis (p < 0.001), although no significant differences were observed in the slope of resistance or in dynamic compliance. Analysis of the asthma patients revealed significant differences between the prebronchodilator and postbronchodilator values for all spirometry and forced oscillation technique parameters. Values of p < 0.001 were obtained for all comparisons between the two groups. CONCLUSION: The modifications provoked by use of the forced oscillation technique were in direct concordance with the pathophysiology of the bronchodilator response in asthma patients, indicating that the forced oscillation technique could be useful as a complement to spirometry in these patients
Disciplines: Medicina
Keyword: Fisiología humana,
Neumología,
Volumen espiratorio forzado,
Oscilometría,
Espirometría,
Asma,
Hiperreactividad bronquial,
Pruebas de provocación,
Bronquios
Keyword: Medicine,
Human physiology,
Pneumology,
Forced expiratory flow,
Oscillometry,
Spirometry,
Asthma,
Bronchial hyperreactivity,
Provocation tests,
Bronchi
Full text: Texto completo (Ver HTML)