| Journal: | Jornal brasileiro de patologia e medicina laboratorial |
| Database: | PERIÓDICA |
| System number: | 000297026 |
| ISSN: | 1676-2444 |
| Authors: | Milito, Cristiane Bedran1 Morais, Jose Carlos Nucci, Marcio Pulcheri, Wolmar Spector, Nelson |
| Institutions: | 1Universidade Federal do Rio de Janeiro, Hospital Universitario Clementino Fraga Filho, Rio de Janeiro. Brasil |
| Year: | 2002 |
| Volumen: | 38 |
| Number: | 4 |
| Pages: | 315-324 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | The non-Hodgkin's lymphomas classifications have been a controversial reason for the last thirty years. Many classifications have been proposed trying to achieve a consensus among pathologists and clinicians. The objective of this study was to analyse critically three of these classifications by the retrospective study of 145 cases of lymph nodes primary lymphomas, selected from the department of Pathology of the Hospital Universitário Clementino Fraga Filho between 1979 and 1995. The revised cases were classifiedby the proposal of Working Formulation, Kiel and Real. Immunohistochemical detections were employed with antibodies anti-CD45, anti-CD20, anti-CD45RO and anti-CD30. One hundred and seven cases (73.7%) showed B phenotype; thirty three cases (22.7%), T phenotype and 4 cases were null (anaplastic large cell lymphomas). It was possible to predict the phenotype by the morphology in 89,4% of the cases.The high grade lymphomas predominated (59.2%), and the centroblastic lymphoma was more frequent (31.7%). The follicular lymphomas account for 29 cases (20%), the large cell type (31%) have more incidence than the small cell type (20%). Comparing the three classifications, we observed that certain Working Formulation's groups agglomerate multiple entities. This occurs because it is based only on morphologic characteristics, hence should not be used. Kiel and Real classifications should have their employ stimulated because they present a good histopathologic analysis, a immunologic study that defines biologic entities correlating, whenever possible, with the postulated normal counterpart |
| Portuguese abstract | Isto se deve ao fato de a classificação da Working Formulation ser baseada somente em achados morfológicos e, por isso, deve ter seu uso desaconselhado. Já a classificação de Kiel e a da Real devem ter o seu emprego estimulado, pois apresentam, além de uma boa análise histopatológica, um estudo imunológico que define entidades biológicas correlacionando-se, quando possível, com a célula de origem |
| Disciplines: | Medicina |
| Keyword: | Hematología, Oncología, Inmunología, Linfoma no Hodgkin, Clasificación, Histopatología |
| Keyword: | Medicine, Hematology, Oncology, Non-Hodgkin lymphoma, Classification, Histopathology, Immunology |
| Full text: | Texto completo (Ver HTML) |
