| Journal: | Jornal brasileiro de patologia e medicina laboratorial |
| Database: | PERIÓDICA |
| System number: | 000297301 |
| ISSN: | 1676-2444 |
| Authors: | Soares, Anna Leticia1 Lasmar, Marcelo Carvalho Garcia, Micheline Lopes Novelli, Bethania Alves2 Lages, Geralda de Fatima Guerra Dusse, Luci Maria Sant'Ana Vieira, Lauro Mello Fernandes, Ana Paula Salles Moura Sousa, Marinez de Oliveira Carvalho, Maria das Gracas |
| Institutions: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 2Santa Casa de Misericordia, Belo Horizonte, Minas Gerais. Brasil |
| Year: | 2006 |
| Season: | Abr |
| Volumen: | 42 |
| Number: | 2 |
| Pages: | 67-75 |
| Country: | Brasil |
| Language: | Portugués |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | BACKGROUND: Hemostatic abnormalities have been associated with vascular complications in patients with type 2 diabetes (DM2). Efficiency of the natural anticoagulation mechanism mediated by proteins C (PC), S (PS) and antithrombin (AT) depends on intact endothelial cells, so the evaluation of these proteins may contribute to a better understanding of the natural anticoagulation status, considering that they inhibit the state of hypercoagulability. OBJECTIVES: The aim of this study was to measure AT, PC and PS levels and the cofactors, factors V (FV) and VIII (FVIII), in subjects with and without DM2 and hypertension (HAS). MATERIAL AND METHOD: 16 healthy subjects (controls), seven patients with DM2, 12 with hypertension (HAS) and 18 with DM2 associated to HAS (DM2 + HAS) were included in this study for natural anticoagulation evaluation. RESULTS: HAS group showed increased levels of AT compared with controls. DM2 + HAS group showed increased levels of PC. For PS and FVIII, no difference was observed among groups. Nevertheless, the increase of FV was observed in DM2 + HAS group, while DM2 group did not show increase. CONCLUSION: AT increase is not yet well known for all conditions. Previous studies have already described PC increase in normoalbuminuric patients with DM2, however its cause is also unknown. FV increase observed in DM2 + HAS group suggests that HAS should contribute to this increase. As FVIII is an acute phase protein the data for FVIII may indicate that assessed subjects had no important inflammatory condition |
| Portuguese abstract | CONCLUSÕES:O aumento da AT é ainda pouco conhecido no meio científico; outros estudos já observaram aumento de PC em pacientes com DM2 e normoalbuminúria, entretanto o mecanismo permanece desconhecido. O aumento de FV observado no grupo DM2 + HAS e não no grupo DM2 pode acontecer em decorrência da HAS. Como o FVIII é uma proteína de fase aguda, a ausência de diferença significativa entre os grupos indica que os indivíduos avaliados não apresentavam processos inflamatórios importantes |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Hematología, Metabolismo y nutrición, Proteína S, Antitrombina, Anticoagulación, Diabetes mellitus tipo 2, Factor V, Factor VIII, Proteína C |
| Keyword: | Medicine, Diagnosis, Hematology, Metabolism and nutrition, Protein S, Antithrombin, Anticoagulation, Diabetes mellitus type 2, Factor V, Factor VIII, Protein C |
| Full text: | Texto completo (Ver HTML) |
