| Journal: | International braz j urol |
| Database: | PERIÓDICA |
| System number: | 000296938 |
| ISSN: | 1677-5538 |
| Authors: | Silva-Ramos, M1 Oliveira, J.M2 Cabeda, J.M Reis, A Soares, J Pimenta, A |
| Institutions: | 1Hospital Geral Santo Antonio, Departamento de Urologia, Porto. Portugal 2Hospital Central Especializado de Criancas Maria Pia, Departamento de Urologia, Porto. Portugal |
| Year: | 2006 |
| Season: | May-Jun |
| Volumen: | 32 |
| Number: | 3 |
| Pages: | 330-335 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | PURPOSE: We examined the significance of the CAG repeat polymorphism in the pathogenesis of cryptorchidism. MATERIALS AND METHODS: Genomic deoxyribonucleic acid (DNA) was extracted from blood samples from 42 cryptorchid boys and from 31 non-cryptorchid control subjects. In the cryptorchid group, 7 had bilateral cryptorchidism and 6 had patent processus vaginalis in the contralateral side. To determine the number of CAG repeats, the DNA was amplified by polymerase chain reaction and sequenced. RESULTS: The mean CAG repeat length in the AR gene was 22.5 (range 16 to 28) in patients and 21.5 (range 17 to 26) in controls (non-significant). Patients with bilateral cryptorchidism had a mean length of 24.3 (range 21 to 26) and patients with unilateral cryptorchidism and patent processus vaginalis in the contra lateral side had a mean of 25.2 (range 21 to 28), which was statistically different from controls (p = 0.015 and p = 0.005 respectively). CONCLUSION: CAG repeat length of the AR gene does not seem to play a major role in patients with unilateral cryptorchidism. However, in patients with bilateral undescended testis, a less functional androgen receptor through a longer polyglutamine chain may have a role in its pathogenesis. In the same way, patients with unilateral cryptorchidism a contralateral patent processus vaginalis have longer CAG repeats that might be responsible for a slower testicular descent and incomplete closure of the processus vaginalis |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Genética, Criptorquidia, Receptores androgénicos, Polimorfismo genético, ADN |
| Keyword: | Medicine, Surgery, Cryptorchidism, Androgen receptors, Genetic polymorphism, DNA, Genetics |
| Full text: | Texto completo (Ver HTML) |
