| Journal: | International braz j urol |
| Database: | PERIÓDICA |
| System number: | 000434823 |
| ISSN: | 1677-5538 |
| Authors: | Viani, Gustavo Arruda1 Hamamura, Ana Carolina1 Correa, Alexandre Ciuffi1 Arruda, Felipe Teles de1 |
| Institutions: | 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil |
| Year: | 2019 |
| Season: | Mar-Abr |
| Volumen: | 45 |
| Number: | 2 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Objective: To build a model to evaluate the impact of salvage radiotherapy (SRT) in men with PSA rise or persistent PSA after undergoing radical prostatectomy (RP). Materials and Methods: The study included 107 node-negative patients treated with SRT after RP at a single institution. Patients received SRT for either prostate-specific antigen (PSA) rising, or PSA persistence after RP. All patients received local radiation to the prostate / seminal vesicle bed. The primary measured outcome was the biochemical recurrence (BCR) free survival. Multivariable Cox regression analysis was used to develop a risk-stratification group to identify predictive factors associated with the probability of BCR at 5yr. Results: At a median follow-up of 52 months, the BCR free survival rate and overall survival in 5 years was 73% and 94%, respectively. At multivariable analysis, pre-SRT PSA level > 0.35ng / mL (p = 0.023), negative margins (p = 0.038), and seminal vesicles invasion (p = 0.001) were significantly associated with BCR free survival. Three risk groups using regression analysis for SRT administration was built. Low-, intermediate- and the high-risk groups had a BCR free survival in 5-years of 96%, 84%, and 44% (p = 0.0001), respectively. Conclusions: We developed a risk group stratification to show the impact of SRT based on prostate cancer characteristics. SRT showed to be extremely beneficial for patients with low- and intermediate-risk tumors. Moreover, the risk-group built could identify patients classified as high-risk who might benefit from more aggressive treatment for SRT |
| Disciplines: | Medicina |
| Keyword: | Urología, Terapéutica y rehabilitación, Oncología, Neoplasias, Próstata, Prostatectomía radical, Radioterapia |
| Keyword: | Urology, Oncology, Therapeutics and rehabilitation, Neoplasms, Prostate, Radiotherapy, Radical prostatectomy |
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