| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000296563 |
| ISSN: | 1677-5538 |
| Autores: | Kim, Yong T1 Kwon, Dong D2 Kim, John Kim, Dae K Lee, Ji Y Chancellor, Michael B |
| Instituciones: | 1Chungbuk National University, Hospital Chungbuk, Cheongju City. Corea del Sur 2University of Pittsburgh, School of Medicine, Pittsburgh, Pensilvania. Estados Unidos de América |
| Año: | 2004 |
| Periodo: | Jul-Ago |
| Volumen: | 30 |
| Número: | 4 |
| Paginación: | 275-278 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | INTRODUCTION: We reviewed our experience with the use of gabapentin to treat symptoms of overactive bladder (OAB) and nocturia in patients who have failed conventional anticholinergic therapy. METHODS: Thirty-one patients referred to us with refractory (OAB) and/or nocturia were treated with oral gabapentin. All the patients had tried or remained on antimuscarinic drugs during treatment. Twenty-four of 31 complained of bothersome symptoms during day and night and the other seven had primary complaints of nocturia. Initial gabapentin doses ranged from 100-300 mg at bedtime. Dose was slowly titrated up to 3,000 mg based on patients' symptomatology and tolerability. RESULTS:The mean age was 51 years old (range 27-78). There were 13 men and 18 women. The median steady state dose chosen by the patient after initial titration was 600 mg/day. Fourteen of 31 patients reported subjective improvement of their frequency and 8 have been on the medication for over 12 months with persistent efficacy. For the 14 improved patients, mean frequency/24 hours decreased from 14.1 ± 2.2 to10.0 + 2.1. Three patients with primary nocturia reported improvement from a mean of 4.0 ± 1.3 to 1.0 ± 0.3 episodes/night. Six patients stopped taking the drug within one month due to side effects mostly described as drowsiness or lethargy. CONCLUSION: Fourteen of 31 patients with refractory (OAB) and nocturia improved with oral gabapentin. Gabapentin was generally well tolerated and can be considered in selective patients when convent |
| Disciplinas: | Medicina |
| Palabras clave: | Cirugía, Terapéutica y rehabilitación, Vejiga, Nocturia, Próstata, Polaquiuria, Neuromodulación, Gabapentina |
| Keyword: | Medicine, Surgery, Therapeutics and rehabilitation, Bladder, Nocturia, Prostate, Pollakiuria, Neuromodulation, Gabapentin |
| Texto completo: | Texto completo (Ver HTML) |
