| Journal: | International braz j urol |
| Database: | PERIÓDICA |
| System number: | 000296564 |
| ISSN: | 1677-5538 |
| Authors: | Faria, Sergio L1 Salah, Mohamud David, Marc Souhami, Luis Duclos, Marie Shenouda, George Deblois, Francois Janick, Christian Freeman, Carolyn R |
| Institutions: | 1Montreal General Hospital, Department of Radio Oncology, Montreal, Quebec. Canadá |
| Year: | 2004 |
| Season: | Jul-Ago |
| Volumen: | 30 |
| Number: | 4 |
| Pages: | 289-295 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico, analítico |
| English abstract | INTRODUCTION: Biochemical failure has been defined as 3 consecutive increases in PSA following curative treatment of prostate cancer. The appropriate management in such cases is controversial. The most usual treatment has been early introduction of hormones. Such patients will live for many years and hormone therapy causes important secondary effects and increases costs. The guideline in our Department of Radiotherapy has been to follow up, with no initial therapy, cases with low PSA and short PSA doubling time. The present study reports this experience. MATERIALS AND METHODS: 528 patients with localized prostate cancer were treated by radical approach between 1992 and 1999, with external radiotherapy, with or without adjuvant hormone therapy. After a median follow-up of 77 months, there were 207 (39%) cases with biochemical failure, 78 of which were followed without therapy after the identification of biochemical failure. All of them were asymptomatic patients and had negative radiographic examinations or did not have imaging exams requested since they presented a favorable outcome. The follow-up included at least 2 annual visits with physical examination and PSA. RESULTS: Of the 78 patients with biochemical failure followed without initial therapy, 7 died from other causes than prostate cancer and the remaining 71 cases were alive and asymptomatic in the last follow-up. Prognostic factors previous to radiotherapy such as stage and Gleason score were not considered when deciding for follow-up without initial therapy in these cases |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Terapéutica y rehabilitación, Próstata, Cáncer, Antígeno prostático específico, Radioterapia, Hormonas |
| Keyword: | Medicine, Surgery, Therapeutics and rehabilitation, Prostate, Cancer, Prostate specific antigen, Radiotherapy, Hormones |
| Full text: | Texto completo (Ver HTML) |
