| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000408505 |
| ISSN: | 1415-4757 |
| Authors: | Machado, Joao Paulo B1 Calil, Iara P1 Santos, Anesia A2 Fontes, Elizabeth P.B1 |
| Institutions: | 1Universidade Federal de Vicosa, Instituto Nacional de Ciencia e Tecnologia em Interacoes Planta-Praga, Vicosa, Minas Gerais. Brasil 2Universidade Federal de Vicosa, Departamento de Biologia Geral, Vicosa, Minas Gerais. Brasil |
| Year: | 2017 |
| Volumen: | 40 |
| Pages: | 292-304 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Due to the limited coding capacity of viral genomes, plant viruses depend extensively on the host cell machinery to support the viral life cycle and, thereby, interact with a large number of host proteins during infection. Within this context, as plant viruses do not harbor translation-required components, they have developed several strategies to subvert the host protein synthesis machinery to produce rapidly and efficiently the viral proteins. As a countermeasure against infection, plants have evolved defense mechanisms that impair viral infections. Among them, the host-mediated translational suppression has been characterized as an efficient mean to restrict infection. To specifically suppress translation of viral mRNAs, plants can deploy susceptible recessive resistance genes, which encode translation initiation factors from the eIF4E and eIF4G family and are required for viral mRNA translation and multiplication. Additionally, recent evidence has demonstrated that, alternatively to the cleavage of viral RNA targets, host cells can suppress viral protein translation to silence viral RNA. Finally, a novel strategy of plant antiviral defense based on suppression of host global translation, which is mediated by the transmembrane immune receptor NIK1 (nuclear shuttle protein (NSP)-Interacting Kinase1), is discussed in this review |
| Disciplines: | Biología |
| Keyword: | Botánica, Fisiología vegetal, Genética, Biología molecular, Inmunidad antiviral, Resistencia genética, Control traduccional |
| Keyword: | Biology, Botany, Genetics, Plant physiology, Molecular biology, Antiviral immunity, Genetic resistance, Translational control |
| Full text: | Texto completo (Ver HTML) |
