| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000459290 |
| ISSN: | 1415-4757 |
| Authors: | Vicari, Marcelo Ricardo1 Bruschi, Daniel Pacheco2 Cabral de Mello, Diogo Cavalcanti3 Nogaroto, Viviane1 |
| Institutions: | 1Universidade Estadual de Ponta Grossa, Departamento de Biologia Estrutural, Molecular e Genetica, Ponta Grossa, Parana. Brasil 2Universidade Federal do Parana, Centro Politecnico, Curitiba, Parana. Brasil 3Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biociencias, Rio Claro, Sao Paulo. Brasil |
| Year: | 2022 |
| Volumen: | 45 |
| Number: | 3 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Descriptivo |
| English abstract | Telomere has a central role in chromosomal stability events. Chromosome ends organized in telomere-loop prevent activation of DNA damage response (DDR) mechanisms, thus keeping the chromosome structure organized. On the other hand, free chromosome ends, dysfunctional telomeres, and interstitial telomeric sequences (ITS) can trigger chromosome rearrangements. Here, the telomere organization, function, and maintenance mechanisms, in addition to ITS types and their involvement in chromosome changes, were revisited. Despite a general (TTAGGG)n sequence being present in vertebrate telomeres, insects show more diversification of their telomere motif. The relation between ITS and chromosome rearrangements was observed in insects and vertebrates, demonstrating different types of genome organization and distribution. Some ITS cannot be considered relicts of chromosome rearrangements because probable they were inserted during a double-strand break repair mechanism. On the other hand, the involvement of telomere sequences participating or triggering chromosome rearrangements or organizing satellite DNA components in several species groups is evident. The genomic assembling advances and applying other methodologies over ITS, and their flanking regions, can help to understand the telomere participation in the chromosomal evolution in species groups with highly diversified karyotypes |
| Disciplines: | Biología |
| Keyword: | Genética, Insectos, Vertebrados, Rearreglo cromosómico, Hibridización, Fluorescencia, Heterocromatina, Telómeros, ITS, Evolución cromosómica, Cariotipos, Revisión bibliográfica |
| Keyword: | Genetics, Insects, Vertebrates, Chromosome rearrangement, Hybridization, Fluorescence, Heterochromatin, Telomeres, ITS, Chromosome evolution, Karyotypes, Bibliographic review |
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