Oxytocin and arginine vasopressin systems in the domestication process
Document title: Oxytocin and arginine vasopressin systems in the domestication process
Journal: Genetics and molecular biology
Database: PERIÓDICA
System number: 000418083
ISSN: 1415-4757
Authors: 1
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Institutions: 1Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Rio Grande do Sul. Brasil
Year:
Season: Mar
Volumen: 41
Pages: 235-242
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental
English abstract Domestication is of unquestionable importance to the technological revolution that has given rise to modern human societies. In this study, we analyzed the DNA and protein sequences of six genes of the oxytocin and arginine vasopressin systems (OXT-OXTR; AVP-AVPR1a, AVPR1b and AVPR2) in 40 placental mammals. These systems play an important role in the control of physiology and behavior. According to our analyses, neutrality does not explain the pattern of molecular evolution found in some of these genes. We observed specific sites under positive selection in AVPR1b ( = 1.429, p = 0.001) and AVPR2 (= 1.49, p = 0.001), suggesting that they could be involved in behavior and physiological changes, including those related to the domestication process. Furthermore, AVPR1a, which plays a role in social behavior, is under relaxed selective constraint in domesticated species. These results provide new insights into the nature of the domestication process and its impact on the OXT-AVP system
Disciplines: Química,
Biología
Keyword: Bioquímica,
Fisiología animal,
Etología,
Oxitocina,
Receptores,
Vasopresina,
Domesticación,
Animales,
Evolución molecular,
Selección positiva
Keyword: Biochemistry,
Animal physiology,
Ethology,
Oxytocin,
Receptors,
Vasopressin,
Domestication,
Animals,
Molecular evolution,
Positive selection
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