| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000459233 |
| ISSN: | 1415-4757 |
| Authors: | Xu, Guofeng1 Fan, Linfeng2 Zhao, Shufeng2 OuYang, Canhui1 |
| Institutions: | 1First Affiliated Hospital of Gannan Medical University, Department of Gastroenterology, Ganzhou, Jiangxi. China 2First Affiliated Hospital of Gannan Medical University, Department of Gastrointestinal Surgery, Ganzhou, Jiangxi. China |
| Year: | 2022 |
| Volumen: | 45 |
| Number: | 1 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| English abstract | Gastric carcinoma (GC) is a malignant tumor that has high mortality and morbidity worldwide. Although many efforts have been focused on the development and progression of GC, the underlying functional regulatory mechanism of GC needs more clarification. Metallothionein 1G (MT1G) is a member of the metallothionein family (MTs), and hypermethylation of MT1G occurred in a variety of cancers, including gastric cancer. However, the functional mechanism of MT1G in GC remains unclear. Here, we demonstrated that MT1G was down-regulated in GC tissues and cells. Overexpression of MT1G inhibited cell proliferation, foci formation and cell invasion, while knockdown of MT1G increased cell proliferation, foci formation and cell invasion. In addition, MT1G overexpression inhibited cell cycle progression and MT1G deficiency exerted opposite phenotype. p-AKT was negatively regulated by MT1G. In summary, our study reveals that MT1G exerts crucial role in regulating of cell proliferation and migration of gastric cancer, providing new insights for MT1G-related pathogenesis and a basis for developing new strategies for treatment of GC |
| Disciplines: | Biología, Medicina |
| Keyword: | Genética, Oncología, PI3K/AKT, GC, MT1G, Cáncer gástrico |
| Keyword: | Genetics, Oncology, MT1G, GC, PI3K/AKT, Gastric cancer |
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