| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000418508 |
| ISSN: | 1415-4757 |
| Authors: | Bejarano, Diego1 Martínez, Rodrigo1 Manrique, Carlos2 Parra, Luis Miguel1 Rocha, Juan Felipe3 Gomez, Yolanda1 Abuabara, Yesid4 Gallego, Jaime5 |
| Institutions: | 1Corporación Colombiana de Investigación Agropecuaria Corpoica, Centro de Investigación "Tibaitatá", Cundinamarca. Colombia 2Universidad Nacional de Colombia, Bogotá. Colombia 3Corporación Colombiana de Investigación Agropecuaria Corpoica, Centro de Investigación Obonuco, Nariño. Colombia 4Corporación Colombiana de Investigación Agropecuaria Corpoica, Centro de Investigación Turipaná, Córdoba. Colombia 5Corporación Colombiana de Investigación Agropecuaria Corpoica, Centro de Investigación El Nus, Medellín, Antioquia. Colombia |
| Year: | 2018 |
| Season: | Jun |
| Volumen: | 41 |
| Number: | 2 |
| Pages: | 426-433 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico |
| English abstract | The linkage disequilibrium (LD) between molecular markers affects the accuracy of genome-wide association studies and genomic selection application. High-density genotyping platforms allow identifying the genotype of thousands of single nucleotide polymorphisms (SNPs) distributed throughout the animal genomes, which increases the resolution of LD evaluations. This study evaluated the distribution of minor allele frequencies (MAF) and the level of LD in the Colombian Creole cattle breeds Blanco Orejinegro (BON) and Romosinuano (ROMO) using a medium density SNP panel (BovineSNP50K_v2). The LD decay in these breeds was lower than those reported for other taurine breeds, achieving optimal LD values (r2 0.3) up to a distance of 70 kb in BON and 100 kb in ROMO, which is possibly associated with the conservation status of these cattle populations and their effective population size. The average MAF for both breeds was 0.27 0.14 with a higher SNP proportion having high MAF values ( 0.3). The LD levels and distribution of allele frequencies found in this study suggest that it is possible to have adequate coverage throughout the genome of these breeds using the BovineSNP50K_v2, capturing the effect of most QTL related with productive traits, and ensuring an adequate prediction capacity in genomic analysis |
| Disciplines: | Medicina veterinaria y zootecnia, Biología |
| Keyword: | Bovinos, Zootecnia, Genética, Razas, BovineSNP50, Desequilibrio de ligamiento, Frecuencia de alelos |
| Keyword: | Bovines, Animal husbandry, Genetics, Creole breeds, BovineSNP50, Linkage disequilibrium, Minor allele frequency |
| Full text: | Texto completo (Ver PDF) |
