In the screening of alternative insecticides to control Aedes aegytpti larvae 2-methylanthraquinone showed no genotoxicity and low toxicity to zebrafish (Danio rerio)
Document title: In the screening of alternative insecticides to control Aedes aegytpti larvae 2-methylanthraquinone showed no genotoxicity and low toxicity to zebrafish (Danio rerio)
Journal: Genetics and molecular biology
Database: PERIÓDICA
System number: 000459230
ISSN: 1415-4757
Authors: 1
1
1
2
2
1
Institutions: 1Universidade de Brasilia, Instituto de Ciencias Biologicas, Brasilia, Distrito Federal. Brasil
2Universidade de Brasilia, Faculdade de Ciencias da Saude, Brasilia, Distrito Federal. Brasil
Year:
Volumen: 45
Number: 1
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, analítico
English abstract The threats posed by insecticide resistance to Aedes aegypti in the context of controlling dengue have led to an urgent search for an environmentally safer alternative chemical with more effective larvicidal properties. Among many molecules tested, 2-methylanthraquinone showed the lowest LC50 for A. aegypti in a previous study and the highest LC50 for zebrafish embryos. Embryos were exposed at concentrations of 1.0, 2.19, 4.78, 10.46, 22.87, 50.0 and 100.0 mg/L, and malformations and mortality were significantly observed only at the highest exposures of 50 and 100 mg/L after 96 h. Micronucleus test and comet assay in zebrafish adults were both negative after exposures at 6.25, 12.5, 25.0, 50.0 and 100.0 mg/L for 96 h. Several biochemical biomarkers were analyzed in adults, and 2-methylanthraquinone did not interfere with acetylcholinesterase activity. The lactate dehydrogenase activity was higher at concentrations of 25 and 100 mg/L. Glutathione-S-Transferase (GST) activities were tested in the gill and body (muscle tail). The gill was more sensitive than body for GST activity after exposure to 2-methylanthraquinone, showing the highest activities, and 2-methylanthraquinone showed low toxicity to a non-target organism
Disciplines: Biología
Keyword: Peces,
Parasitología,
Genética,
Aedes aegytpti,
Larvas,
Insecticidas,
Danio rerio,
Dengue
Keyword: Fish,
Parasitology,
Genetics,
Aedes aegytpti,
Larvae,
Insecticides,
Danio rerio,
Dengue
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