| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000337196 |
| ISSN: | 1415-4757 |
| Authors: | Silveira, Luiz Guilherme G1 Furlan, Luiz Roberto1 Curi, Rogerio A1 Ferraz, Andre Luiz J1 Alencar, Mauricio Mello de2 Regitano, Luciana C.A2 Martins, Cyntia Ludovico1 Arrigoni, Mario de Beni1 Suguisawa, Liliane1 Silveira, Antonio C1 Oliveira, Henrique N. de1 |
| Institutions: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina Veterinaria e Zootecnia, Botucatu, Sao Paulo. Brasil 2Empresa Brasileira de Pesquisa Agropecuaria, Centro de Pesquisa de Pecuaria do Sudeste, Sao Carlos, Sao Paulo. Brasil |
| Year: | 2008 |
| Season: | Dic |
| Volumen: | 31 |
| Number: | 4 |
| Pages: | 874-879 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | The growth hormone 1 gene (GH1) is a candidate gene for body weight and weight gain in cattle since it plays a fundamental role in growth regulation. We investigated the GH1 gene AluI and DdeI restriction enzyme polymorphisms, located 149 bp apart in the cattle genome, as possible markers of the production potential of Canchim crossbreed cattle, a 5/8 Charolais (Bos taurus) and 3/8 Nelore (Bos indicus) breed developed in Brazil, by evaluating the birth weight, weaning weight, yearling weight and plasma insulin-like growth factor-1 (IGF-1) concentration of 7 month to 10 months old Canchim calves (n = 204) of known genealogy and which had been genotyped for the AluI and DdeI markers. Our results showed significant effect (p < 0.05) between the homozygous DdeI+/DdeI+ polymorphism and the estimated breeding value for weaning weight (ESB-WW), while the AluI leucine homozygous (L/L) and leucine/valine (L/V) heterozygous polymorphisms showed no significant effect on the traits studied. The restriction sites of the two enzymes led to the formation of haplotypes which also exerted a significant effect (p < 0.05) on the ESB-WW, with the largest difference being 8.5 kg in favor of the homozygous L plus DdeI+/L plus DdeI+ genotype over the heterozygous L plus DdeI-/V plus DdeI+ genotype |
| Disciplines: | Química, Biología, Medicina veterinaria y zootecnia |
| Keyword: | Bioquímica, Genética, Zootecnia, Ganado vacuno, Polimorfismo, Hormona del crecimiento, Genes candidatos |
| Keyword: | Chemistry, Biology, Veterinary medicine and animal husbandry, Biochemistry, Genetics, Animal husbandry, Beef cattle, Polymorphism, Growth hormone, Candidate gene |
| Full text: | Texto completo (Ver PDF) |
