| Journal: | Ecletica quimica |
| Database: | |
| System number: | 000552810 |
| ISSN: | 0100-4670 |
| Authors: | Malik, Suman1 Das, Supriya1 Jain, Bharti2 |
| Institutions: | 1Sadhu Vaswani College, Department of Chemistry, Bairagarh, India., 2Sarojni Naidu Government Girls College, Department of Chemistry, Bhopal, India., |
| Year: | 2011 |
| Volumen: | 36 |
| Number: | 3 |
| Pages: | 31-36 |
| Country: | Brasil |
| Language: | Inglés |
| English abstract | Omeprazole (OME) is a proton pump inhibitor (PPI). PPI"s have enabled to improve the treatment of various acidpeptic disorders. OME is a weak base and it can form several complexes with transition and non-transitions metal ions. In the present paper, we are describing series of trantion metal complexes of omeprazole i.e.,5-methoxy-2[(4methoxy-3,5dimethyl-2-pyridinyl)methylsulfinyl]–1H–benzimidazole with CuII, MnII, CoII, NiII, FeII, ZnII and HgII. These complexes were characterized by elemental analysis, molar conductance, IR, NMR, magnetic susceptibility, UV-visible spectral studies, ESR, SEM and X-ray diffraction. Based on the above studies, the ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and S=O groups .The complexes were found to non-electrolytic in nature on the basis of low values of molar conductance . Analytical data and stochiometry suggest ligand metal ratio of 2:1 for all the complexes. Electronic Spectra and Magnetic susceptibility measurements reveal octahedral geometry for Mn(II),Co(II), Ni(II),Fe(II) and Cu(II) complexes and tetrahedral for Hg(II) and Zn(II) complexes. Ligands and their metal complexes have been screened for their antibacterial and antifungal activities against bacteria Pseudomonas, Staphylococcus Aureus and fungi Aspergillus niger and A. flavous. |
| Keyword: | Omeprazole, Spectroscopy study, Molar condutance |
| Full text: | Texto completo (Ver PDF) |
