Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds
Document title: Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds
Journal: Ecletica quimica
Database: PERIÓDICA
System number: 000367173
ISSN: 0100-4670
Authors: 1
1
1
Institutions: 1Universidad Nacional de Colombia, Departamento de Farmacia, Bogotá. Colombia
Year:
Season: Oct-Dic
Volumen: 33
Number: 4
Pages: 33-40
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Based on published thermodynamic quantities for solution, partitioning and sublimation of acetanilide (ACN), acetaminophen (ACP) and Phenacetin (PNC), the thermodynamic quantities for drugs solvation in octanol-saturated water (W(ROH)) and water-saturated octanol (ROH(W)) as well as the drugs dilution in ROH(W) were calculated. The Gibbs energies of solvation were favourable in all cases. The respective enthalpies and entropies were negative indicating an enthalpy-driving for the solvation process in all cases. On the other hand, the Gibbs energies of dilution were favourable for ACP and PNC but unfavourable for ACN, whereas the respective enthalpies and entropies were negative for ACP and PNC but positive for ACN indicating enthalpy-driving for the dilution process in the case of the former drugs and entropy-driving for the latter. From the obtained values for the transfer processes, an interpretation based on solute-solvent interactions was developed
Disciplines: Química
Keyword: Química farmacéutica,
Solvatación,
Acetanilida,
Acetaminofén,
Fenacetina,
Coeficiente de partición,
Octanol
Keyword: Chemistry,
Medicinal chemistry,
Solvation,
Acetanilide,
Acetaminophen,
Phenacetin,
Partition coefficient,
Octanol
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