| Journal: | Colombia médica |
| Database: | PERIÓDICA |
| System number: | 000425572 |
| ISSN: | 0120-8322 |
| Authors: | Velasco Benítez, Carlos Alberto1 Ruiz Extremera, Angeles2 Matallana Rhoades, Audrey Mary1 Giraldo Lora, Sandra Carolina1 Ortiz Rivera, Claudia Jimena1 |
| Institutions: | 1Universidad del Valle, Escuela de Medicina, Cali, Valle del Cauca. Colombia 2Universidad de Granada, Granada. España |
| Year: | 2018 |
| Season: | Oct-Dic |
| Volumen: | 49 |
| Number: | 4 |
| Pages: | 273-279 |
| Country: | Colombia |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| Spanish abstract | A pesar que la asociación entre diabetes mellitus tipo 1 (DMT1) y enfermedad celíaca (EC) está bien establecida; hay pocos estudios en niños suramericanos sobre haplotipos y sus posibles asociaciones. Objetivo: Determinar la prevalencia de marcadores de EC en un grupo de niños con DMT1, analizando las manifestaciones clínicas, inmunológicas y genéticas. Métodos: Estudio de prevalencia en niños con DMT1 a quienes se les tomaron variables sociodemográficas, antropométricas, de la enfermedad, paraclínicas y familiares metabólicas. A los niños con IgA anti-transglutaminasa (tTG2) positivos, se les realizó biopsia duodenal y genotipo. Se estimó la proporción de niños con DMT1 y EC y su IC 95%; medidas de tendencia central, análisis univariado y bivariado, siendo significativa una p <0.05. Resultados: Trece (8.4%) de los 155 niños (53.6% niñas, de 11.0 ±3.6 años, 2-18 años) con DMT1 fueron tTG2 positivos, cuatro presentaron EC (2.6%), siete EC potencial (4.5%) y nueve HLA DQ2/DQ8 (5.8%). Los niños con DMT1 y EC presentaron más pronto su último episodio cetoacidótico (21.5 ±30.4 meses versus 69.5 ±38.8 meses, p= 0.0260) que los niños con DMT1 y EC potencial. No hubo diferencias con la antropometría ni con los paraclínicos del control glicémico. Conclusiones: La prevalencia de EC en estos niños con DMT1 es superior a la de otros países suramericanos; estando asociada al tiempo de presentación de la DMT1 y su principal alelo el DQ2/ DQ8, hallazgos diferentes a lo descrito a nivel mundial |
| English abstract | Although the association between diabetes mellitus type 1 (T1DM) and celiac disease (CD) is well established; there are only a few studies that focus on South American children, haplotypes and their possible associations. Objective: To determine the prevalence of CD markers in a group of children with T1DM and to analyze the associated clinical, immunological and genetic manifestations. Methods: A prevalence study focusing on children with T1DM who were assessed based on variables including sociodemographics, anthropometric information, disease characteristics, laboratory results and family medical history. In partitipants a positive tTG2 (Ig A antitransglutaminase), a duodenal biopsy and genotype were performed. The proportion of children with T1DM and CD was estimated (CI 95%). Determinations of central tendency, univariate and bivariate analysis, were also performed; p <0.05 was considered significant. Results: Thirteen (8.4%) of the 155 children (53.6% girls, 11.0 ±3.6 years, 2-18 years) with T1DM were tTG2 positive, four had CD (2.6%), seven had potential CD (4.5%) and nine were HLA DQ2/DQ8 positive (5.8%). Children with T1DM and CD had their last ketoacidotic episode (21.5 ±30.4 months versus 69.5 ±38.8 months, p= 0.0260) earlier than children with T1DM and potential CD. There were no differences with anthropometry or with the laboratory results regarding glycemic control. Conclusions: The prevalence of CD in these children with T1DM is higher than that reported in other South American countries. The prevalence of CD was found to be associated with the time of presentation of T1DM and its main allele, the DQ2/DQ8. These findings are different from what has been described in other places around the world |
| Disciplines: | Medicina |
| Keyword: | Pediatría, Endocrinología, Metabolismo y nutrición, Niños, Diabetes, Enfermedad celíaca, Haplotipos, Prevalencia, Transglutaminasa, Prolaminas |
| Keyword: | Pediatrics, Endocrinology, Metabolism and nutrition, Children, Diabetes, Celiac disease, Haplotypes, Prevalence, Transglutaminase, Prolamines |
| Full text: | Texto completo (Ver PDF) |
