| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451877 |
| ISSN: | 1984-8250 |
| Authors: | Favarin, Fernanda Reis1 Gündel, Samanta da Silva1 Ledur, Cristian Mafra1 Roggia, Isabel1 Fagan, Solange Binotto1 Gündel, André2 Fogaça, Aline de Oliveira1 Ourique, Aline Ferreira1 |
| Institutions: | 1Universidade Franciscana, Programa de Graduacao em Nanociencias, Santa Maria, Rio Grande do Sul. Brasil 2Universidade Federal do Pampa, Departamento de Fisica, Bage, Rio Grande do Sul. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | The objective of this study was to evaluate the influence of vitamin C (VC) on the stability of stored liposomes under different climatic conditions. Liposomal formulations containing 1 mg/mL of VC (LIP-VC) and blank formulations (LIP-B) were prepared by the reverse-phase evaporation method. After preparation, they were characterized according to their refractive index, average vesicle diameter, polydispersity index (PDI), zeta potential, pH, content, encapsulation efficiency (EE%), morphology, stability and antioxidant activity. For stability, LIP-VC and LIP-B were stored in different climatic conditions (4 °C, 25 °C and 40 °C) for 30 days. The LIP-VC presented 1.3365 refractive index, 161 nm of mean diameter, 0.231 PDI, -7.3 mV zeta potential, 3.2 pH, 19.4% EE%, spherical morphology, 1 mg/mL of VC content, and antioxidant activity of 12 and 11.4 μmol of TE/mL for the radical DPPH and ABTS+, respectively. During stability, the LIP-B stored in 40 °C showed an instability in the parameters: PDI, vesicle size and zeta potential after 15 days, while the LIP-VC remained stable in its size and PDI for 30 days. After that, it is shown that VC can be used as an antioxidant and stabilizer in liposomes to increase the stability and shelf-life of vesicles |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Acido ascórbico, Antioxidantes, Nanoliposomas, Actividad antioxidante, Evaporación de fase reversa |
| Keyword: | Medicinal chemistry, Ascorbic acid, Antioxidants, Nanoliposomes, Antioxidant activity, Reverse-phase evaporation |
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