| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452106 |
| ISSN: | 1984-8250 |
| Authors: | Silveira, Anna Luísa Oliveira1 Alves, Geisa Cristina da Silva1 Xie, Jiao2 Roberts, Jason A2 Sanches, Cristina1 |
| Institutions: | 1Universidade Federal de Sao Joao del Rei, Campus Centro-Oeste, Divinopolis, Minas Gerais. Brasil 2The University of Queensland, Centre for Clinical Research, Brisbane, Queensland. Australia |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | To analyze microbiological effectiveness of vancomycin in children from a pediatric hospital through population pharmacokinetic modelling, as well as to propose dose adjustment, a cross- sectional study was performed in children under vancomycin treatment from the John Paul II Children’s Hospital, MG. In order to establish a model, concentrations versus time curves were analyzed using a population pharmacokinetic approach with Pmetrics®. Seventeen blood samples of 10 patients were collected. The best model to describe vancomycin population pharmacokinetic (PK) consisted of a two-compartment linear intravenous absorption model. The R² value and bias for population and individuals in observed versus predicted plot was 0.642 vs. 0.992 and the bias of 0.41 mg/L and 0.0778 mg/L, respectively. The covariables creatinine clearance, age, and body mass index were related to vancomycin PK. A relevant PK variability for vancomycin in pediatric patients was verified, which was significantly influenced by creatinine clearance, age, and body mass index. This result justifies the formulation of dosing recommendations for vancomycin in pediatric patients to achieve adequate pharmacodynamics targets |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Pediatría, Antibióticos, Vancomicina, Farmacocinética |
| Keyword: | Pharmacology, Pediatrics, Antibiotics, Vancomycin, Pharmacokinetics |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
