| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451231 |
| ISSN: | 1984-8250 |
| Authors: | Leite Silva, Vânia Rodrigues1 Silva, Camila Vieira da1 Higuchi, Celio Takashi1 Silva, Heron Dominguez Torres da1 Duque, Marcelo Dutra1 Andréo Filho, Newton1 Lopes, Patrícia Santos1 Martins, Tereza Silva1 |
| Institutions: | 1Universidade Federal de Sao Paulo, Instituto de Ciencias Ambientais, Quimicas e Farmaceuticas, Diadema, Sao Paulo. Brasil |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Urea’s thermal instability and burning on sensitive skin can cause problems for cosmetic formulations. To overcome these drawbacks, urea was incorporated into ordered mesoporous silica (SBA-15). SBA-15 was synthesized using tetraethyl orthosilicate and Pluronic® P123 in an acid medium. Urea (20 wt.%) was incorporated into calcined SBA-15 by the incipient wetness impregnation method. Several techniques were used to characterize the samples. Skin hydration and transepidermal water loss were measured using Corneometer® CM 825 PC and Tewameter® 300 TM. Results showed that the structural properties of SBA-15Urea were similar to pure SBA-15, indicating that SBA-15 remained structured even after urea incorporation. Nitrogen physisorption data showed the volume and surface area of the pores in SBA-15Urea were much lower than those in SBA-15, demonstrating that urea was deposited inside the mesopores. In vivo moisturization studies revealed that SBA-15Urea was not able to reduce transepidermal water loss compared to the other products and control, while forming a non-occlusive surface film on the skin. We conclude that incorporation of urea in the pores of the inorganic SBA-15 matrix is a promising approach to enhancing its stability and providing a prolonged moisturizing effect |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Cosmetología, Urea, Formulaciones cosméticas, Sílica mesoporosa |
| Keyword: | Medicinal chemistry, Cosmetology, Urea, Cosmetic formulations, Mesoporous silica |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
