Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
Document title: Thrombolysis, clotting, and genotoxic activities modulated by essential oils extracted from Lippia alba
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451876
ISSN: 1984-8250
Authors: 1
1
1
1
Institutions: 1Universidade Federal de Lavras, Departamento de Quimica, Lavras, Minas Gerais. Brasil
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract The composition and pharmacological properties of Lippia alba (Mill.) (L. alba) (Verbenaceae) flower and leaf essential oils (EO) were determined in this study. The major constituents in the flower EO were geranial (49.83%) and neral (32.75%), and in the leaf EO were geranial (38.06%), neral (31.02%), and limonene (18.03%). Flower EO inhibited thrombolysis induced by Bothrops moojeni (B. moojeni) and Lachesis muta muta (L. muta muta) venoms (0.05-1.2 µL mL-1). When tested against L. muta muta venom, the protective effect was smaller in both EO. The EOs prolonged the clotting time induced by L. muta muta venom and a procoagulant effect was observed on B. moojeni. In the comet assay, the flower EO presented anti-genotoxic action (damage frequency of only 11.6 - 34.9%) against the L. muta muta venom. The positive control (Doxorubicin) and the venom alone presented a damage frequency of 80.3% and 70.7%, respectively. The flower EO protected DNA from damage induced by L. muta muta venom. L. alba leaf and flower EOs presented anti-genotoxic action
Disciplines: Química,
Biología
Keyword: Angiospermas,
Fitoquímica,
Aceites esenciales,
Inhibidores enzimáticos,
Hemostasis,
Lippia alba,
Verbenaceae
Keyword: Angiosperms,
Phytochemistry,
Essential oils,
Enzyme inhibitors,
Hemostasis,
Lippia alba,
Verbenaceae
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