Therapeutic effects of benzoylaconitine and paeoniflorin in rats with collagen-induced arthritis
Document title: Therapeutic effects of benzoylaconitine and paeoniflorin in rats with collagen-induced arthritis
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451797
ISSN: 1984-8250
Authors: 1
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Institutions: 1University of Electronic Science and Technology of China, School of Medicine, Chengdu, Sichuan. China
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract To explore the effects and mechanisms of benzoylaconitine and paeoniflorin on collagen-induced arthritis (CIA) rats. Weight, paw swelling, arthritis index and joint pathologic changes were examined in each group after CIA induction. PGE2, IL-1β, IL-6, IL-10, TNF-α, VEGF, MMP-3, IgG and anti-CII Ab were assessed by ELISA; STAT1 and STAT3 expressions were analyzed immunohistochemically, and the ultrastructure of synovial cells was observed by transmission electron microscopy. Therapeutic effects were determined in CIA rats via injecting benzoylaconitine and paeoniflorin, which could alleviate the degree of swelling and arthritis index (AI) and pathological lesions of the sacroiliac gland; decrease the levels of PGE2, IL-1β, TNF-α, VEGF and IgG in serum; reduce STAT1 and STAT3 expression in the membrane tissue; and inhibit the secretion and proliferation of synovial cells. These results showed that benzoylaconitine and paeoniflorin could significantly palliate the arthritic symptoms of CIA rats, and better therapeutic effects could be achieved if the two components were used in combination
Disciplines: Medicina
Keyword: Reumatología,
Farmacología,
Medicina experimental,
Artritis,
Benzoilaconitina,
Paeoniflorina,
Mecanismos celulares,
Ratas
Keyword: Rheumatology,
Experimental medicine,
Pharmacology,
Arthritis,
Benzoylaconitine,
Paeoniflorin,
Cellular mechanisms,
Rats
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